Greater effectiveness of ε-viniferin in red wine than its monomer resveratrol for inhibiting vascular smooth muscle cell proliferation and migration

• ZGHONDA Nahla

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• YOSHIDA Shigeki

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• ARAKI Masahiro

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• KUSUNOKI Miki

  Graduate School of Life and Environmental Sciences, University of Tsukuba

• MLIKI Ahmed

  Laboratory of Molecular Physiology of Grapevine, Biotechnology Center

• GHORBEL Abdelwahed

  Laboratory of Molecular Physiology of Grapevine, Biotechnology Center

• MIYAZAKI Hitoshi

  Graduate School of Life and Environmental Sciences, University of Tsukuba

書誌事項

タイトル別名

• Greater Effectiveness of .EPSILON.-Viniferin in Red Wine Than Its Monomer Resveratrol for Inhibiting Vascular Smooth Muscle Cell Proliferation and Migration
• Greater effectiveness of e viniferin in red wine than its monomer resveratrol for inhibiting vascular smooth muscle cell proliferation and migration

抄録

Resveratrol is a strong candidate for explaining an irreversible correlation between red wine consumption and coronary heart disease. The present study examined the effect of ε-viniferin, a dehydrodimer of resveratrol, on vascular smooth muscle cells (VSMCs), because ε-viniferin functions are poorly understood in spite of its comparable content to resveratrol in red wines and grapes. Both ε-viniferin and resveratrol inhibited platelet-derived growth factor-induced cell proliferation, migration, and reactive oxygen species (ROS) production, in addition to inducing nitric oxide generation. ε-Viniferin was more effective than resveratrol in these effects, except for inhibiting ROS production. The compounds also increased the expression of the antioxidant enzyme, hemeoxygenase-1, via transcription factor Nrf2. The phosphatidylinositol 3-kinase-Akt pathway was implicated in resveratrol-dependent nuclear Nrf2 accumulation, whereas extracellular signal-regulated kinase and p38 were involved in ε-viniferin-induced Nrf2 accumulation. These data suggest that ε-viniferin may function more effectively than resveratrol in different mechanisms and cooperatively with resveratrol in preventing atherosclerosis.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 75 (7), 1259-1267, 2011

  公益社団法人 日本農芸化学会

キーワード

• resveratrol
• ε-viniferin
• vascular smooth muscle cells
• nuclear factor-E2-related factor 2
• hemeoxygenase-1

詳細情報

• CRID: 1390282681453657472
• NII論文ID: 10029328919
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.110022
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 11174207
• PubMed: 21737923
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11174207
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110022
• Web Site: https://search.jamas.or.jp/link/ui/2011339589
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可