Prevention of Oxidative DNA Degradation by Copper-Binding Peptides
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- YOKAWA Ken
- Laboratory of Chemical Biology and Environmental Engineering, Faculty and Graduate School of Environmental Engineering, The University of Kitakyushu
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- KAGENISHI Tomoko
- Laboratory of Chemical Biology and Environmental Engineering, Faculty and Graduate School of Environmental Engineering, The University of Kitakyushu
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- KAWANO Tomonori
- Laboratory of Chemical Biology and Environmental Engineering, Faculty and Graduate School of Environmental Engineering, The University of Kitakyushu
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Free divalent ions of copper (Cu) are capable of generating radical species such as hydroxyl radicals in the presence of hydrogen peroxide or ascorbic acid through Harbor-Weiss-like reactions under physiological conditions. It has been reported that radical-mediated damage to DNA molecules in animal cells leads to programmed cell death. Hence it is important to seek for methods to prevent Cu-mediated DNA damage. In this study we identified on effect of Cu binding of short peptides (chiefly Gly-Gly-His tripeptide) in the prevention of DNA degradation caused by Cu-mediated reactions in the presence of hydrogen peroxide and of ascorbic acid.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (7), 1377-1379, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390282681453634176
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- NII論文ID
- 10029329520
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 11175191
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- PubMed
- 21737913
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可