Role of Right Ventricular Systolic Function on Long-Term Outcome in Patients With Newly Diagnosed Systolic Heart Failure

• Chrysohoou Christina

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Antoniou Christos-Konstantinos

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Kotrogiannis Iason

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Metallinos George

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Aggelis Athanasios

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Andreou Ioannis

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Brili Stella

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Pitsavos Christos

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

• Stefanadis Christodoulos

  Heart Failure Unit, 1^st Department of Cardiology, Hippokration General Hospital, School of Medicine, University of Athens

抄録

Background: Right ventricular (RV) systolic function has been recognized as a prognostic factor in endstage heart failure (HF) patients and in the present study we evaluated the effect of this dysfunction on prognosis in patients with newly-diagnosed systolic HF. Methods and Results: We enrolled 180 consecutive patients with newly diagnosed systolic HF (ischemic or dilated cardiomyopathy). Echocardiographic evaluation was performed to assess biventricular function. Pulse-wave tissue Doppler imaging (TDI) readings were obtained from the lateral tricuspid annulus and the peak systolic annular velocity (Stv) was recorded. Patients were followed for a 2-year period and events (death or HF hospitalization) were recorded. During the follow-up, 79 patients (44%) had an adverse event. An inverse relationship was observed between the height of Stv and the probability of an event (odds ratio (OR) 0.716, 95% confidence interval (CI) 0.583-0.880, P=0.001), after controlling for potential confounders. Furthermore, creatinine clearance (CrCl) was inversely associated with the outcome: a 1-unit increase in CrCl was associated with a 0.98-times lower likelihood of having an event. When the analysis was stratified by CrCl <60ml/min or ≥60ml/min, Stv predicted adverse events in both groups (CrCl <60ml/min: OR 0.62, 95%CI 0.39-0.98, P=0.04; CrCl ≥60ml/min: OR 0.78, 95%CI 0.61-1.01, P=0.06). Conclusions: Pulse-wave TDI readings of peak systolic velocity at the lateral tricuspid annulus, reflecting RV systolic function, has prognostic significance in newly-diagnosed systolic HF patients. (Circ J 2011; 75: 2176-2181)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 75 (9), 2176-2181, 2011

  一般社団法人 日本循環器学会

キーワード

• Echocardiography
• Heart failure
• Prognosis
• Renal function
• Right ventricle

詳細情報

• CRID: 1390001205103524096
• NII論文ID: 10029339643
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-11-0296
• COI: 1:STN:280:DC%2BC3MjoslKgug%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 21778591
• Web Site: http://www.jstage.jst.go.jp/article/circj/75/9/75_CJ-11-0296/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012074589
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可