癌の「分子標的予防」　　‐その理論と可能性‐

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  • 酒井 敏行
    京都府立医科大学大学院医学研究科分子標的癌予防医学

書誌事項

タイトル別名
  • "Molecular-Targeting Prevention" of Cancer -The Theory and Its Possibilities-
  • 学会賞受賞論文 癌の「分子標的予防」--その理論と可能性
  • ガッカイショウ ジュショウ ロンブン ガン ノ ブンシ ヒョウテキ ヨボウ ソノ リロン ト カノウセイ
  • —The Theory and Its Possibilities—
  • ―その理論と可能性―

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抄録

In previous prevention studies, molecular targets were not intended. We then proposed the concept termed “molecular-targeting prevention” and applied it to cancer prevention. In most malignant tumors, tumor-suppressor genes, the retinoblastoma gene (RB) and/or the p53 gene are considered to be inactivated. We therefore hypothesized that RB and/or p53 might be good candidates for the molecular-targeting prevention of cancer. Interestingly, many cancer-preventive food factors were found to reactivate the lost functions of RB and/or p53 by a “gene-regulating chemoprevention” strategy. We next proposed the concept termed “combination-oriented molecular-targeting prevention”, in which only the preventive effects are synergistically enhanced. We then investigated the TNF-related apoptosis-inducing ligand (TRAIL)-death receptor 5 (DR5) pathway as a candidate of the target, and found that many cancer-preventive food factors could enhance the pathway resulting in the synergistic apoptosis of various cancer cells. We hope that these strategies will contribute to the prevention of cancer.<br>

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