双生児家系縦断データに基づくライフコース遺伝疫学研究の展望

• 大木 秀一

  石川県立看護大学健康科学講座

書誌事項

タイトル別名

• Life Course Genetic Epidemiologic Study Based on Longitudinal Twin-Family Data: A New Perspective
• ソウセイジ カケイ ジュウダン データ ニ モトズク ライフコース イデンエキガク ケンキュウ ノ テンボウ

抄録

Family-based life course epidemiology is the approach to clarify long-term effects of accumulations and chains of biological and social risk exposures in one’s life trajectory, namely, before and during conception, infancy, childhood, young adulthood and later adult life. Both genetic and environmental factors are considered. One of the theoretical rationales is the ‘developmental origin of health and disease (DOHaD)’ hypothesis. According to this theory, the causes of adult diseases are attributed to predictive adaptive responses and biological programming or epigenetic changes during a critical period of early life. If the environment later in life after birth is different from what is predicted, a mismatch has happened, leading to the development of a disease. This theory is supported by many epidemiologic studies, animal experiments, and evolution theory of biology. Longitudinal twin-family data are very powerful and useful information in the family-based life course genetic epidemiologic study.<br>

収録刊行物

• 日本衛生学雑誌

  日本衛生学雑誌 66 (1), 31-38, 2011

  一般社団法人日本衛生学会

キーワード

• ライフコース疫学
• 家系ベースの研究
• 健康と疾患の発達起源仮説
• 双生児家系縦断研究
• ライフコース因果関係モデル

詳細情報

• CRID: 1390001206362391040
• NII論文ID: 10029363640
• NII書誌ID: AN00185923
• DOI: 10.1265/jjh.66.31
• ISSN: 18826482
• ISSN: 00215082
• NDL書誌ID: 11003498
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11003498
• Web Site: http://www.jstage.jst.go.jp/article/jjh/66/1/66_1_31/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011155435
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可