人血清アルブミンを含まないインターフェロン-α凍結乾燥製剤の製剤設計

• 山下 親正

  大塚製薬株式会社

書誌事項

タイトル別名

• Design of a Freeze-Dried Human Serum Albumin-Free Formulation of Interferon-α

抄録

The purpose of this study was to develop a freeze-dried human serum albumin (HSA)-free formulation of interferon-α (IFN-α) that had high safety and stability to reduce the risk of contamination in preparation of a pathogenic virus, an infectious prion and unknown infection factor. As a result, the usefulness of L-leucine as not only a new stabilizer of IFN-α, but also an excipient for improving appearance and foaming at reconstitution of lyophilized cake was discovered. Moreover, a combination of polysorbate 80, sucrose, L-leucine, glycine and citrate buffer was found to the most stable, improving the appearance and foaming of a freeze-dried HSA-free formulation of IFN-α.

収録刊行物

• 薬剤学

  薬剤学 71 (1), 58-64, 2011

  公益社団法人 日本薬剤学会

キーワード

• IFN-α
• HSA free
• stability
• hydrophobic amino acids
• freeze-dried formulation

詳細情報

• CRID: 1390564238078744448
• NII論文ID: 10029415789
• NII書誌ID: AN00266708
• DOI: 10.14843/jpstj.71.58
• ISSN: 21883149
• ISSN: 03727629
• Web Site: https://search.jamas.or.jp/link/ui/2011112827
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可