免疫固定法によるＭ蛋白検出とＶＥＧＦ高値で診断したＰＯＥＭＳ症候群

DOI Web Site 参考文献5件

書誌事項

タイトル別名
  • POEMS syndrome diagnosed by detection of M-protein on immunofixation and increased level of vascular endothelial growth factor
  • メンエキ コテイホウ ニ ヨル M タンパク ケンシュツ ト VEGF コウチ デ シンダン シタ POEMS ショウコウグン

この論文をさがす

抄録

A 48-year-old male with Castleman disease developed symptoms typical of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal-protein and skin changes) but M-protein was not detected by immunoelec-trophoresis. He was diagnosed as having POEMS syndrome based on IgA-λ detected by immunofixation electrophoresis and an increased level (3,170 pg/ml) of vascular endothelial growth factor (VEGF). After diagnosis, the patient underwent autologous peripheral blood stem cell transplantation safely and remained relapse-free and in good condition for 15 months. This case suggests that immunofixation electrophoresis and detection of elevated serum VEGF level are useful methods for earlier diagnosis of POEMS syndrome.

収録刊行物

  • 臨床血液

    臨床血液 52 (4), 219-222, 2011

    一般社団法人 日本血液学会

参考文献 (5)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ