Relationship Between Coronary Plaque Vulnerability and Serum n-3/n-6 Polyunsaturated Fatty Acid Ratio
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- Kashiyama Toshikazu
- Cardiovascular Division, Osaka Police Hospital
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- Ueda Yasunori
- Cardiovascular Division, Osaka Police Hospital
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- Nemoto Takayoshi
- Cardiovascular Division, Osaka Police Hospital
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- Wada Mitsuru
- Cardiovascular Division, Osaka Police Hospital
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- Masumura Yuki
- Cardiovascular Division, Osaka Police Hospital
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- Matsuo Koshi
- Cardiovascular Division, Osaka Police Hospital
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- Nishio Mayu
- Cardiovascular Division, Osaka Police Hospital
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- Hirata Akio
- Cardiovascular Division, Osaka Police Hospital
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- Asai Mitsutoshi
- Cardiovascular Division, Osaka Police Hospital
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- Kashiwase Kazunori
- Cardiovascular Division, Osaka Police Hospital
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- Kodama Kazuhisa
- Cardiovascular Division, Osaka Police Hospital
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Background: A low ratio of serum eicosapentaenoic acid to arachidonic acid (EPA/AA) has been associated with cardiovascular events. Higher-grade yellow color coronary plaques are associated with higher plaque vulnerability and higher thrombogenic potential. Therefore, the association between EPA/AA ratio and yellow color grade of coronary plaques was examined. Methods and Results: Consecutive patients (n=54) who underwent percutaneous coronary intervention were enrolled in this study. The serum EPA/AA ratio was examined on admission. All patients underwent an angioscopic examination of the culprit vessel to examine the color grade of yellow plaques (0, white; 1, slight yellow; 2, yellow; and 3, intense yellow) and the presence of thrombus. Excluding 16 patients with acute coronary syndrome (ACS), 38 patients with stable angina were divided into 2 groups according to their EPA/AA ratio: the low EPA/AA group (n=19, EPA/AA ratio <0.37 [median]) and the high EPA/AA group (n=19, EPA/AA ratio ≥0.37). The maximum color grade (2.5±0.5 vs. 1.9±0.9; P=0.01) of yellow plaques was significantly higher and the number of non-culprit yellow plaques with thrombus (1.7±0.8 vs. 1.2±1.1; P=0.06) tended to be higher in low EPA/AA than in high EPA/AA stable angina patients. Multivariate analysis revealed that the serum EPA level (odds ratio=0.98, 95% confidence interval=0.96-0.99, P=0.03) was associated with the presence of grade-3 yellow plaques. Conclusions: A low serum EPA level and a low EPA/AA ratio was associated with high vulnerability of coronary plaques. (Circ J 2011; 75: 2432-2438)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 75 (10), 2432-2438, 2011
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680078484992
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- NII論文ID
- 10029459623
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- NII書誌ID
- AA11591968
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- COI
- 1:CAS:528:DC%2BC3MXhtleku7vN
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- ISSN
- 13474820
- 13469843
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- PubMed
- 21778590
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
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