Method of simultaneous stir bar sorptive extraction of phenethylamines and THC metabolite from urine

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  • Goto Yoshiyuki
    Forensic Science Laboratory, Kumamoto Prefectural Police Headquarters Environmental and Symbiotic Science Prefectural University of Kumamoto
  • Takeda Shiho
    Forensic Science Laboratory, Kagoshima Prefectural Police Headquarters Environmental and Symbiotic Science Prefectural University of Kumamoto
  • Araki Toshinori
    Forensic Science Laboratory, Kumamoto Prefectural Police Headquarters
  • Fuchigami Takayuki
    Forensic Science Laboratory, Kumamoto Prefectural Police Headquarters

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Stir bar sorptive extraction is a technique used for extracting target substances from various aqueous matrixes such as environmental water, food, and biological samples. This type of extraction is carried out by rotating a coated stir bar is rotated in the sample solution. In particular, Twister bar is a commercial stir bar that is coated with polydimethylsiloxane (PDMS) and used to perform sorptive extraction. In this study, we developed a method for simultaneous detection of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and a Δ9-tetrahydrocannabiniol (THC) metabolite in human urine. For extracting the target analytes, the Twister bar was simply stirred in the sample in the presence of a derivatizing agent. Using this technique, phenethylamines and the acidic THC metabolite can be simultaneously extracted from human urine. This method also enables the extraction of trace amounts of these substances with good reproducibility and high selectivity. The proposed method offers many advantages over other extraction-based approaches and is therefore well suited for screening psychoactive substances in urine specimens.

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