Relationship between Clinical Markers of Glycemia and Glucose Excursion Evaluated by Continuous Glucose Monitoring (CGM).
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- SUWA Tomoko
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- OHTA Akio
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- MATSUI Tomoya
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- KOGANEI Rieko
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- KATO Hiroyuki
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- KAWATA Takehiro
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- SADA Yukiyoshi
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- ISHII Satoshi
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- KONDO Akihiko
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- MURAKAMI Kaori
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- KATABAMI Takuyuki
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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- TANAKA Yasushi
- Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine, Kanagawa, Japan
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In order to evaluate the relationship between clinical markers of glycemia and glucose excursion, we performed 48-hour continuous glucose monitoring (CGM) in 43 diabetic patients. For the clinical markers, HbA1c, glycoalbumin (GA), and 1,5-anhydroglucitol (1,5-AG) were measured, and for the parameters of glucose excursion from CGM, average glucose (AG), standard deviation of glucose (SD), the area under the curve for glucose levels >180 mg/dL (AUC>180), and the difference between the maximum and minimum glucose levels during 48 hours (ΔG48hr) were analyzed. All patients were treated without any changes of the dosages of oral anti-diabetic agents or insulin for at least the previous 3 months with coefficient of variation (CV) of HbA1c less than 4 %. In results, while HbA1c did not show any single correlation with AG, SD, AUC>180, or ΔG48hr, both GA and 1,5-AG were significantly related to all these parameters. Furthermore, GA significantly correlated to all CGM parameters, and SD significantly correlated to GA in multiple regression analyses. These results suggest that GA may be a different marker from HbA1c for diabetic complications, because GA, but not HbA1c, may reflect not only short-term average glucose but also fluctuation of glucose.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 57 (2), 135-140, 2010
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681276592256
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- NII論文ID
- 10029583647
- 130004443611
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- NII書誌ID
- AA10901436
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- COI
- 1:STN:280:DC%2BC3c7ktFansg%3D%3D
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- ISSN
- 13484540
- 09188959
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- PubMed
- 19926921
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可