Post-Translational Isoprenylation of Tryptophan

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Abstract

<I>Bacillus subtilis</I> and related bacilli produce a post-translationally modified oligopeptide, ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComX pheromones are formed by geranylation or farnesylation on a tryptophan residue at the 3 position of its indole ring. This results in the formation of a tricyclic structure including, a newly formed five-membered ring, similar to proline. Isoprenylation of ComX to form ComX pheromones is essential for pheromonal activity, and is functionally more crucial than its amino acid sequence. The ComX pheromone is the first example of isoprenoidal modifiations of tryptophan residues in living organisms and post-translational isoprenylation of any amino acid in prokaryotes. Because the presence of geranylated compounds is unusual in primary and secondary metabolites outside the plant kingdom, post-translational geranylation in bacilli is unprecedented in nature.

Journal

Bioscience, Biotechnology, and Biochemistry  

Bioscience, Biotechnology, and Biochemistry 75(8), 1413-1417, 2011-08-23 

Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  39

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Codes

  • NII Article ID (NAID) :
    10029590897
  • NII NACSIS-CAT ID (NCID) :
    AA10824164
  • Text Lang :
    ENG
  • Article Type :
    REV
  • ISSN :
    09168451
  • NDL Article ID :
    11222009
  • NDL Source Classification :
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-G223
  • Databases :
    CJP  NDL  J-STAGE