CLINICOPATHOLOGICAL SIGNIFICANCE OF KI-67 ANTIBODY LABELING INDEX FOR PATIENTS WITH SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS
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- TABATA Koki
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- MIYATA Kanji
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- YUASA Norihiro
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- TAKEUCHI Eiji
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- GOTO Yasutomo
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- MIYAKE Hideo
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- NAGAI Hidemasa
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- KOBAYASHI Yoichiro
- Department of Surgery, Japanese Red Cross Nagoya Daiichi Hospital
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- KAJIURA Dai
- Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
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- ITO Masafumi
- Department of Pathology, Japanese Red Cross Nagoya Daiichi Hospital
Bibliographic Information
- Other Title
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- 食道扁平上皮癌におけるKi‐67標識率の臨床病理学的意義
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Abstract
Background : Ki-67 antibody labeling index (MIB-1) is an indicator of cell proliferation, and has been investigated in carcinoma of the lung and breast. However, its correlation with clinicopathological significance and prognosis in squamous cell carcinoma (SCC) of the esophagus has not been determined.<BR>Patients and Methods : Twenty-five patients who underwent potentially curative resection for SCC of the esophagus in the hospital between 2006 and 2008 were enrolled in this study. Patients who had preoperative radio-and/or chemotherapy were excluded. Clinicopathological factors, prognosis of the patients and correlation between the MIB-1 of the primary tumors and the maximum standardized uptake values (max-SUV) in fluorodeoxyglucose positron emission tomography (FDG-PET) were investigated.<BR>Results : The mean MIB-1 was 42.3 % (range, 13.0-73.2 %), and it was significantly correlated with lymph node metastasis (p=0.002) and pathological stage (p=0.007). Patients with high MIB-1 (more than 40 %) showed a significantly poor disease-free survival compared with those with low MIB-1 (less than 40%) (p=0.035). Weak correlation was found between the MIB-1 and max-SUV (p=0.051).<BR>Conclusion : The MIB-1 has a significant correlation with lymphatic extension and pathological stage, and can be a prognostic parameter. MaxSUV might be a predictive factor of prognosis.
Journal
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- Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
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Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 72 (6), 1347-1354, 2011
Japan Surgical Association
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Keywords
Details 詳細情報について
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- CRID
- 1390001204851951360
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- NII Article ID
- 130004517911
- 10029612082
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- NII Book ID
- AA11189709
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- ISSN
- 18825133
- 13452843
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed