The Development of Classically and Alternatively Activated Macrophages Has Different Effects on The Varied Stages of Radiation-induced Pulmonary Injury in Mice

DOI PDF Web Site 被引用文献1件 参考文献60件
  • ZHANG Hui
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors
  • HAN Guang
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors Department of Radiotherapy, Hubei Cancer Hospital
  • LIU Hui
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors
  • CHEN Ji
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors
  • JI Xuemei
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors
  • ZHOU Fuxiang
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors
  • ZHOU Yunfeng
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors
  • XIE Conghua
    Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors

この論文をさがす

抄録

The classical and alternative activation of macrophages has been proposed to play a role in radiation-induced pneumonitis and fibrosis, respectively. To test this hypothesis, the thoraces of C57BL/6 mice were irradiated with 12 Gy X-rays, and irradiated and control mice were euthanized at 1, 8, 12, 24 and 72 hours, and 2, 4, 8, 16 and 24 weeks after irradiation. The expression of inducible nitric oxide synthase (iNOS) and arginase type 1 (Arg-1) was evaluated at the mRNA and protein levels at different stages post-irradiation. We demonstrated that the enhanced mRNA and protein expression of iNOS occurred within the pneumonic stage, whereas the high levels of Arg-1 expression occurred within the fibrotic phase. Immunohistochemistry revealed that iNOS and Arg-1 were mainly expressed in macrophages. The expression of iNOS and Arg-1 may be associated with acute radiation pneumonitis and the development of radiation fibrosis, respectively. Although the function of macrophages cannot explain the whole process of radiation-induced pulmonary injury development, it may play an important regulatory role during this process.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (60)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ