Study of the Response of Superoxide Dismutase in Mouse Organs to Radon Using a New Large-scale Facility for Exposing Small Animals to Radon

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We examined dose–dependent or dose rate–dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m<sup>3</sup> for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m<sup>3</sup>, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose–rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.

We examined dose–dependent or dose rate–dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m<sup>3</sup> for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m<sup>3</sup>, activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose–rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.

収録刊行物

  • Journal of radiation research  

    Journal of radiation research 52(6), 775-781, 2011-11-16 

    Journal of Radiation Research Editorial Committee

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各種コード

  • NII論文ID(NAID)
    10029653106
  • NII書誌ID(NCID)
    AA00705792
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    04493060
  • NDL 記事登録ID
    023320732
  • NDL 請求記号
    Z53-P232
  • データ提供元
    CJP書誌  CJP引用  NDL  IR  J-STAGE 
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