Expression of Hypoxia-inducible Factor 1α Predicts Clinical Outcome after Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer
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- SHIOYA Mariko
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
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- TAKAHASHI Takeo
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
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- ISHIKAWA Hitoshi
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
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- SAKURAI Hideyuki
- Department of Radiation Oncology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
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- EBARA Takeshi
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
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- SUZUKI Yoshiyuki
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
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- SAITOH Jun-ichi
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
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- OHNO Tatsuya
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
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- ASAO Takayuki
- Department of General Surgical Science, Gunma University Graduate School of Medicine
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- KUWANO Hiroyuki
- Department of General Surgical Science, Gunma University Graduate School of Medicine
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- NAKANO Takashi
- Department of Radiation Oncology, Gunma University Graduate School of Medicine
書誌事項
- タイトル別名
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- Expression of Hypoxia-inducible Factor 1.ALPHA. Predicts Clinical Outcome after Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer
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抄録
Hypoxia-inducible factor 1α (HIF-1α) is an intrinsic marker of tumor hypoxia. It has been considered that hypoxic conditions reduce radiosensitivity, but the role of HIF-1α in patients treated with preoperative therapy for rectal cancer is still unclear. The aim of this study was to evaluate the predictive value of tumor response to preoperative hyperthermo-chemoradiotherapy (HCRT) and the prognostic significance of HIF-1α expression in patients with locally advanced rectal cancer. Between 2003 and 2006, 50 patients with histologically proven rectal adenocarcinoma who underwent HCRT followed by surgery were investigated. HIF-1α expression was immunohistochemically evaluated using pre-treatment biopsies. The total radiation dose was 40–50 Gy and chemotherapy consisted of 5-FU and LV administered by continuous infusion on Day 1–5, Day 15–19, and Day 29–33 during radiotherapy. Hyperthermia treatment was performed for once a week for 2–5 sessions. The surgical operation was performed 8 weeks after HCRT and each resected specimen was graded by histological criteria of the Japanese Classification of Colorectal Carcinoma. The effects of HIF-1α on clinical outcomes were analyzed by univariate and multivariate analysis. Positive HIF-1α expression was recognized in 42.0% of samples (21/50). Resected specimens that showed pathological grades 1, 2, and 3 numbered 17, 24, and 9 cases, respectively. There were no significant differences between the HIF-1α-positive group and HIF-1α-negative group for pathological grading and pCR. Overall survival (OS) rate at 3 years in the HIF-1α-negative group was 85.2%, which was significantly better than the 60.6% in the HIF-1α-positive group. Recurrence-free survival (RFS) rate at 3 years in the HIF-1α-negative group was 82.8%, being significantly better than 47.6% in the HIF-1α-positive group. In addition, elevated HIF-1α expression was significantly correlated with recurrence-free survival and metastasis-free survival rate in multivariate analysis. HIF-1α expression might be predictive of recurrence-free survival and metastasis-free survival rate for rectal cancer patients treated with HCRT.
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 52 (6), 821-827, 2011
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282680191845504
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- NII論文ID
- 10029653265
- 50008191637
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:DC%2BC38%2FhsVaktA%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 023320808
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- PubMed
- 22104271
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可