細胞防御因子としての細胞内tumor necrosis factorの意義

• 渡辺 直樹

  札幌医科大学医学部附属病院検査部

書誌事項

タイトル別名

• Endogenous Tumor Necrosis Factor Acts as a Cytoprotective Factor.

抄録

Endogenous tumor necrosis factor (enTNF) participates in intrinsic resistance against heat not only via induction of manganous superoxide dismutase (MnSOD) but also via enhancement of the heat shock element (HSE) -binding activity of heat shock factor 1 (HSF 1) followed by augmentation of HSP 72 expression. These findings suggenst that enTNF may be useful as a predictor of heat sensitivity and that the resistance to heat could be overcome by antisense TNF gene transfer designed to inhibit enTNF expression.

収録刊行物

• 日本ハイパーサーミア学会誌

  日本ハイパーサーミア学会誌 14 (2), 99-107, 1998

  日本ハイパーサーミア学会

キーワード

• endogenous tumor necrosis factor (enTNF)
• manganous superoxide dismutase (MnSOD)
• heat shock proteins (HSPs)
• heat sensitivity

詳細情報

• CRID: 1390282679328029312
• NII論文ID: 130003646556
• NII論文ID: 10029673980
• NII書誌ID: AN10084762
• DOI: 10.3191/thermalmedicine.14.99
• ISSN: 18819516
• ISSN: 09112529
• Web Site: http://www.jstage.jst.go.jp/article/thermalmedicine1985/14/2/14_2_99/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999236496
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可