書誌事項
- タイトル別名
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- Exposure to Nanoparticle-Rich Diesel Exhaust May Cause Liver Damage
- ナノ リュウシ オ オオク フクム ディーゼル ハイキ ガス バクロ ニ ヨル カンゾウ エ ノ エイキョウ
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Diesel exhaust (DE) is one of the air pollutants in the world, and exposure to DE is an environmental health concern. Most studies amongst the limited number of studies on hepatotoxicity have focused on genotoxicity or mutagenicity. However, DE exposure may cause liver damage because one prospective study suggests that DE exposure is associated with increased mortality due to arteriosclerosis and cirrhosis of the liver. Peroxisome proliferator-activated receptor (PPAR) α plays a role in the regulation of lipid homeostasis and inflammation and thereby may be involved in the progression of atherosclerosis. We investigated whether nanoparticle-rich diesel exhaust (NR-DE) affects the liver and how PPARα is involved in the NR-DE induced effects. We report these results briefly in this minireview. Our results suggest NR-DE-induced hepatic inflammation and dyslipidemia. PPARα may be involved in the development of these disorders.<br>
収録刊行物
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- 日本衛生学雑誌
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日本衛生学雑誌 66 (4), 638-642, 2011
一般社団法人日本衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282681338479104
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- NII論文ID
- 10029679776
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- NII書誌ID
- AN00185923
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- ISSN
- 18826482
- 00215082
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- NDL書誌ID
- 11270169
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可