Pilot study demonstrating that immunostimulation with β glucan fails to moderate the immunosuppressive effects of dexamethasone when co-administered to rainbow trout Oncorhynchus mykiss experimentally challenged with the microsporidian Loma salmonae
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- Speare David J.
- Department of Pathology & Microbiology, Atlantic Veterinary College
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- Guselle Nicole J.
- Department of Pathology & Microbiology, Atlantic Veterinary College
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- Harkness Jennifer E.
- Department of Pathology & Microbiology, Atlantic Veterinary College
書誌事項
- タイトル別名
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- Pilot Study Demonstrating that Immunostimulation with .BETA. glucan Fails to Moderate the Immunosuppressive Effects of Dexamethasone when Co-administered to Rainbow Trout Oncorhynchus mykiss Experimentally Challenged with the Microsporidian Loma salmonae
- Pilot study demonstrating that immunostimulation with ベータ glucan fails to moderate the immunosuppressive effects of dexamethasone when co administered to rainbow trout Oncorhynchus mykiss experimentally challenged with the microsporidian Loma salmonae
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In this pilot study, juvenile rainbow trout were experimentally challenged with the microsporidian Loma salmonae to determine the effects of immunostimulation with β-1,3/1,6 glucan administered in the feed at 200 mg/kg of feed, and immunosuppression with dexamethasone at 300 mg/kg of feed when these were administered in the early stages of infection. Six weeks after oral exposure to Loma spores, control fish developed a mean of 34.8 spore filled xenomas per gill arch; those which had received β glucan had significantly fewer xenomas (23.6) whereas those receiving dexamethasone had significantly more (43.0). Paradoxically, when fish received both β glucan and dexamethasone in any of three temporal combinations, xenoma numbers were significantly higher (51.0-65.1) even when compared to fish receiving only dexamethasone.
収録刊行物
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- 魚病研究
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魚病研究 46 (3), 95-97, 2011
日本魚病学会
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詳細情報 詳細情報について
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- CRID
- 1390282681438736256
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- NII論文ID
- 10029692395
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- NII書誌ID
- AN00063165
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- ISSN
- 18817335
- 0388788X
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- NDL書誌ID
- 11249596
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可