Effects of Methoxsalen from<i>Poncirus trifoliata</i>on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

• KIM Jae Kyeom

  Department of Food and Biotechnology, Korea University Department of Food Science and Nutrition, University of Minnesota

• CHOI Soo Jung

  Graduate School of Life Sciences and Biotechnology, Korea University Plants for Human Health Institute, North Carolina State University

• BAE Hyeri

  Department of Food and Biotechnology, Korea University

• KIM Cho Rong

  Department of Food and Biotechnology, Korea University

• CHO Hong-Yon

  Department of Food and Biotechnology, Korea University

• KIM Young Jun

  Department of Food and Biotechnology, Korea University

• LIM Seung Taik

  Graduate School of Life Sciences and Biotechnology, Korea University

• KIM Chang-Ju

  Department of Physiology, Kyung Hee University

• KIM Hye Kyung

  Department of Food and Biotechnology, Hanseo University

• PETERSON Sabrina

  Department of Food Science and Nutrition, University of Minnesota

• SHIN Dong Hoon

  Department of Food and Biotechnology, Korea University

書誌事項

タイトル別名

• Effects of Methoxsalen from Poncirus trifoliata on Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

抄録

Previously, we identified methoxsalen (8-methoxy-2′,3′,6,7-furocoumarin) as the bioactive compound probably responsible for acetylcholinesterase (AchE) inhibition achieved by feeding crude extract of Poncirus trifoliate. To confirm the activity of methoxsalen, Institute of Cancer Research (ICR) mice were fed a control or a methoxsalen-supplemented diet for 4 weeks, and then learning and memory enhancing effects with respect to trimethyltin (TMT)-induced neurotoxicity were evaluated. The brain tissues of ICR mice were dissected after completion of the behavioral tests for biochemical analysis. Methoxsalen effectively reversed TMT-induced memory impairment on both Y-maze and passive avoidance tests. Brain AchE activity was inhibited by the oral consumption of all concentrations of methoxsalen. Moreover, the level of oxidative stress was significantly ameliorated in the groups on methodsalen containing diets. This is the first in vivo study conducted with methoxsalen in the field of AD research, and it indicates that further investigation of methoxsalen is warranted.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 75 (10), 1984-1989, 2011

  公益社団法人 日本農芸化学会

キーワード

• methoxsalen (8-methoxy-2′,3′,6,7-furocoumarin)
• <I>Poncirus</I> <I>trifoliata</I>
• Alzheimer’s disease
• acetylcholinesterase
• anti-oxidative activity

詳細情報

• CRID: 1390282681454515840
• NII論文ID: 10029873018
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.110386
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 11286541
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11286541
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110386
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可