Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor 7 activating protease) autoactivation

• YAMAMOTO Eisaku

  Department of Applied Biological Science, Tokyo University of Agriculture and Technology

• KITANO Yoshikazu

  Department of Applied Biological Science, Tokyo University of Agriculture and Technology

• HASUMI Keiji

  Department of Applied Biological Science, Tokyo University of Agriculture and Technology

書誌事項

タイトル別名

• Elucidation of Crucial Structures for a Catechol-Based Inhibitor of Plasma Hyaluronan-Binding Protein (Factor VII Activating Protease) Autoactivation

抄録

Plasma hyaluronan-binding protein (PHBP) is a serine protease the activation of which is implicated in inflammation. Previous investigations have suggested the presence of catechol-binding sites in its proenzyme form, pro-PHBP. Here we found that compounds with plural catechol groups conjugated with strong electron-withdrawing groups, such as tyrphostin AG 537 (IC₅₀=18 nM), were potent inhibitors of pro-PHBP activation.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 75 (10), 2070-2072, 2011

  公益社団法人 日本農芸化学会

キーワード

• plasma hyaluronan-binding protein
• factor VII activating protease
• autoactivation
• inhibitor
• proteolysis

詳細情報

• CRID: 1390001206477918208
• NII論文ID: 10029873414
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.110515
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 11286948
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11286948
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.110515
• 本文言語コード: en
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