Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms
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- Jutabha Promsuk
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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- Anzai Naohiko
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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- Kimura Toru
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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- Taniguchi Atsuo
- Institute of Rheumatology, Tokyo Women’s Medical University, Japan
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- Urano Wako
- Institute of Rheumatology, Tokyo Women’s Medical University, Japan
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- Yamanaka Hisashi
- Institute of Rheumatology, Tokyo Women’s Medical University, Japan
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- Endou Hitoshi
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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- Sakurai Hiroyuki
- Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan
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We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [14C]para-aminohippurate, [3H]bumetanide, [3H]estrone sulfate, and [14C]urate, when each variant clone was expressed in the plasma membrane of oocytes. This study suggests the possibility that the genetic variation of NPT4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate.
収録刊行物
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 115 (2), 249-253, 2011
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205181390336
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- NII論文ID
- 10029892290
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- NII書誌ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL書誌ID
- 10979917
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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