Experimental Model of Naturally Occurring Post-radiation Sarcoma: Interest of Positron Emission Tomography (PET) for Early Detection

• PHULPIN Bérengère

  Head and Neck Surgery and Dental Units, Oncologic Surgery Department, Centre Alexis Vautrin EA4421 SIGReTO Nancy University, Faculty of Medicine

• TRAN Nguyen

  School of Surgery, INSERM U961, Faculty of Medicine, Nancy University

• LEROUX Agnès

  EA4421 SIGReTO Nancy University, Faculty of Medicine Pathology and Tumor Biology Department, Centre Alexis Vautrin

• POUSSIER Sylvain

  INSERM U961, Faculty of Medicine, Nancy University

• MARIE Pierre-Yves

  INSERM U961, Faculty of Medicine, Nancy University

• PINEL Sophie

  EA4421 SIGReTO Nancy University, Faculty of Medicine

• HUGER Sandrine

  Radiotherapy Department, Centre Alexis Vautrin

• HENROT Philippe

  Radiology Department, Centre Alexis Vautrin

• GALLET Patrice

  EA4421 SIGReTO Nancy University, Faculty of Medicine

• BLAISE Claire

  EA4421 SIGReTO Nancy University, Faculty of Medicine

• BRAVETTI Pierre

  Oral Surgery Department, Faculty of Dentistry, Nancy University

• GRAFF Pierre

  Radiotherapy Department, Centre Alexis Vautrin

• MERLIN Jean-Louis

  EA4421 SIGReTO Nancy University, Faculty of Medicine Pathology and Tumor Biology Department, Centre Alexis Vautrin

• DOLIVET Gilles

  Head and Neck Surgery and Dental Units, Oncologic Surgery Department, Centre Alexis Vautrin EA4421 SIGReTO Nancy University, Faculty of Medicine

抄録

Radiotherapy is an integral part of overall cancer therapy. One of the most serious adverse effects of irradiation concern, for long-term survivors, the development of post-radiation sarcoma (PRS) in healthy tissues located within the irradiated area. PRS have bad prognosis and are often detected at a late stage. Therefore, it is obvious that the early detection PRS is a key-point and the development of preclinical models is worthy to evaluate innovative diagnostic and therapeutic procedures. The aim of this study was to develop a spontaneous murin model of PRS and to evaluate the potency of Positron Emission Tomography (PET) for early detection. Fifteen Wistars rats were irradiated unilateraly on the hindlimb with a single dose of 30 Gy. Sequential analysis was based on observational staging recordings, Computerized Tomography (CT) scanning and PET. Tumors were removed and, histopathological and immunochemistry analyses were performed. Among the irradiated rats, 12 sarcomas (80%) were detected. All tumors occurred naturallty within the irradiated hindlimb and were highly aggressive since most tumors (75%) were successfully transplanted and maintained by serial transplantation into nude mice. Upon serial staging recordings, using PET, was found to enable the detection of PRS earlier after irradiation than with the other methods (i.e. 11.9 ± 1.8 vs 12.9 ± 2.6 months). These results confirmed the interest of experimental models of PRS for the preclinical evaluation of innovative diagnostic strategies and confirmed the potency of PET for early detection of PRS. This preclinical model of PRS can also be proposed for the evaluation of therapeutic strategies.

収録刊行物

• Journal of Radiation Research

  Journal of Radiation Research 53 (1), 101-109, 2012

  Journal of Radiation Research 編集委員会

キーワード

• Rat model
• Post-radiation sarcoma
• MicroPET

詳細情報

• CRID: 1390282680194385408
• NII論文ID: 10030023708
• NII書誌ID: AA00705792
• DOI: 10.1269/jrr.11008
• ISSN: 13499157
• ISSN: 04493060
• NDL書誌ID: 023407843
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023407843
• Web Site: http://academic.oup.com/jrr/article-pdf/53/1/101/2706920/jrr-53-101.pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013012100
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可