Impaired Mobilization of CD133⁺ Bone Marrow-Derived Circulating Progenitor Cells With an Increased Number of Diseased Coronary Arteries in Ischemic Heart Disease Patients With Diabetes

• Turan R. Goekmen

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Turan C. Hakan

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Bozdag-Turan Ilkay

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Ortak Jasmin

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Akin Ibrahim

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Kische Stephan

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Schneider Henrik

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Kleinfeldt Tilo

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Rehders Tim C.

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Rauchhaus Mathias

  Applied Cachexia Research, Department of Cardiology Campus Virchow-Klinikum, Charité-Universitätsmedizin

• Adolph Esther

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Amen Shwan

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Hermann Tina

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Yokus Sedat

  Laboratory of Stem Cell Transplantation and Molecular Cardiology, Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University

• Brehm Micheal

  Laboratory of Stem Cell Transplantation and Molecular Cardiology, Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University

• Steiner Stephan

  Laboratory of Stem Cell Transplantation and Molecular Cardiology, Department of Internal Medicine, Division of Cardiology, Pneumology and Angiology, Heinrich-Heine-University

• Sahin Kurtulus

  Institute for Clinical Research and Statistics

• Nienaber Christoph A.

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

• Ince Hueseyin

  Department of Internal Medicine, Division of Cardiology, University Hospital Rostock

抄録

Background: The influence of the number of diseased coronary arteries on the mobilization of CD133/45⁺ bone marrow-derived circulating progenitor cells (BM-CPCs) in peripheral blood (PB) in patients with ischemic heart disease (IHD) was analyzed. Methods and Results: Mobilization of CD133/45⁺ BM-CPCs by flow cytometry was measured in 120 patients with coronary 1 vessel (IHD1, n=40), coronary 2 vessel (IHD2, n=40), and coronary 3 vessel disease (IHD3, n=40), and in a control group (n=40). The mobilization of CD133/45⁺ BM-CPCs was significantly reduced in patients with IHD compared to the control group (P<0.001). The mobilization of CD133/45⁺ BM-CPCs was impaired in patients with IHD3 compared to IHD1 (P<0.001) and to IHD2 (P<0.001). But there was no significant difference in mobilization of CD133/45⁺ BM-CPCs between the patients with IHD2 and IHD1 (P=0.35). Moreover, we found significantly reduced CD133/45⁺ cell mobilization in patients with a high SYNTAX-Score (SS) compared to a low SS (P<0.001) and an intermediate SS (P<0.001). In subgroup analyzes, we observed a significantly negative correlation between levels of hemoglobin A_1c and the mobilization of CD133/45⁺ BM-CPCs (P=0.001, r=-0.6). Conclusions: The mobilization of CD133/45⁺ BM-CPCs in PB is impaired in patients with IHD. This impairment might augment with increased number of diseased coronary arteries. Moreover, mobilization of CD133/45⁺ BM-CPCs in ischemic tissue is further impaired by diabetes in patients with IHD. (Circ J 2011; 75: 2635-2641)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 75 (11), 2635-2641, 2011

  一般社団法人 日本循環器学会

キーワード

• CD133/45⁺
• Diabetes
• Ischemic heart disease
• Mobilization

詳細情報

• CRID: 1390282680081037568
• NII論文ID: 10030032323
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-10-1284
• ISSN: 13474820
• ISSN: 13469843
• Web Site: https://www.jstage.jst.go.jp/article/circj/75/11/75_CJ-10-1284/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012169910
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可