Soluble lectin-like oxidized LDL receptor-1 and high-sensitivity troponin T as diagnostic biomarkers for acute coronary syndrome -improved values with combination usege in emergency rooms

• Kobayashi Nobuaki

  Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School

• Hata Noritake

  Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School

• Kume Noriaki

  Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

• Shinada Takuro

  Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School

• Tomita Kazunori

  Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School

• Shirakabe Akihiro

  Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School

• Kitamura Mitsunobu

  Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School

• Nozaki Ayaka

  Division of Intensive Care Unit, Chiba Hokusoh Hospital, Nippon Medical School

• Inami Toru

  Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School

• Seino Yoshihiko

  Department of Internal Medicine, Chiba Hokusoh Hospital, Nippon Medical School

• Mizuno Kyoichi

  Division of Cardiology, Hepatology, Geriatrics and Integrated Medicine, Department of Internal Medicine, Nippon Medical School

書誌事項

タイトル別名

• Soluble Lectin-Like Oxidized LDL Receptor-1 and High-Sensitivity Troponin T as Diagnostic Biomarkers for Acute Coronary Syndrome - Improved Values With Combination Usage in Emergency Rooms -
• – Improved Values With Combination Usage in Emergency Rooms –

抄録

Background: Although highly sensitive assays for troponin T (hs-TnT) have been developed, the sensitivity and specificity of hs-TnT for diagnosing acute coronary syndrome (ACS) remains imperfect. We evaluated the diagnostic value of a new biomarker of plaque vulnerability (soluble lectin-like oxidized low-density lipoprotein receptor-1, sLOX-1) as compared with hs-TnT in the emergency room (ER). Methods and Results: Plasma sLOX-1 and serum hs-TnT levels were measured in 200 consecutive patients presenting with chest symptoms and ECG abnormalities in the ER (116 ST elevation ACS [STEACS], 44 non-ST elevation ACS [NSTEACS], 40 non-ACS). The non-ACS group consisted of patients with cardiovascular diseases such as coronary spastic angina pectoris, pulmonary thromboembolism, perimyocarditis and takotsubo cardiomyopathy. Levels of sLOX-1 and hs-TnT were significantly higher in STEACS and NSTEACS than in non-ACS patients. The receiver-operating characteristic (ROC) curves of sLOX-1 and hs-TnT for detecting ACS, using the non-ACS patients as negative references, showed that the area under the curve (AUC) values of sLOX-1 and hs-TnT were 0.769 and 0.739, respectively. In the lower hs-TnT (<0.0205ng/ml) subgroup, the AUC value of the ROC curve of sLOX-1 for detecting ACS was 0.869. Conclusions: The diagnostic value for ACS was comparable between sLOX-1 and hs-TnT, and the accuracy of ACS diagnosis appeared to improve when sLOX-1 and hs-TnT were measured in combination. (Circ J 2011; 75: 2862-2871)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 75 (12), 2862-2871, 2011

  一般社団法人 日本循環器学会

キーワード

• High-sensitivity troponin T
• Myocardial damage
• Plaque instability
• Plaque rupture
• Soluble lectin-like oxidized low-density lipoprotein receptor-1

詳細情報

• CRID: 1390001205102553728
• NII論文ID: 10030033518
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-11-0724
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/75/12/75_CJ-11-0724/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012170751
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可