Effects of sustained stimulation with multi-wall carbon nanotubes on immune and inflammatory responses in mice

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  • Yamaguchi Atsumi
    Departments of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • Fujitani Tomoko
    Departments of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • Ohyama Ken-ichi
    Departments of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
  • Nakae Dai
    Departments of Pharmaceutical Sciences, Tokyo Metropolitan Institute of Public Health
  • Hirose Akihiko
    Divisions of Risk Assessment, National Institute of Health Science
  • Nishimura Tetsuji
    Divisions of Environmental Chemistry, National Institute of Health Science
  • Ogata Akio
    Departments of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health

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Possible effects of multi-wall carbon nanotubes (MWCNTs) on immune and inflammatory responses were examined in mice. Female ICR mice were given a single intraperitoneal administration (2 mg/kg body weight) of either MWCNTs, carbon black (CB), or crocidolite (blue asbestos) and controls received a vehicle of 2% sodium carboxymethyl cellulose (CMC Na). In the peritoneal cavity of MWCNT-administered mice, the liver had changed to a rounded shape and fibrous adhesions were seen on internal organs. Peritoneal cells overexpressed mRNA for genes of T helper (Th)2 cytokines (interleukin [IL]-4, IL-5, and IL-13), Th17 cytokine (IL-17), pro-inflammatory cytokines/chemokines (IL-1β, IL-33, tumor necrosis factor α, and monocyte chemotactic protein-1), and myeloid differentiation factor 88 for at least 2 weeks after the administration of MWCNTs, while those of Th1 cytokine genes (IL-2 and interferon γ) were overexpressed several weeks later and expression levels remained high up to 20 weeks. In MWCNT-treated mice, the numbers of leukocytes, monocytes, and granulocytes in the peripheral blood and the expression of the leukocyte adhesion molecules, cluster of differentiation (CD)49d and CD54, on granulocytes were increased 1 week after administration and remained high up to week 20. Production of ovalbumin-specific IgM and IgG1 was enhanced by MWCNTs. These changes were not observed after CB or crocidolite administration. Thus, this study showed that MWCNTs exhibited sustained stimulating effects on immune and inflammatory responses, unlike the other mineral fibers with structural similarities.

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