Genetic, Molecular and Cellular Mechanisms Underlying the J Wave Syndromes

• Antzelevitch Charles

  Masonic Medical Research Laboratory Masonic Medical Research Laboratory

抄録

An early repolarization (ER) pattern in the ECG, distinguished by J-point elevation, slurring of the terminal part of the QRS and ST-segment elevation has long been recognized and considered to be a benign electrocardiographic manifestation. Experimental studies conducted over a decade ago suggested that some cases of ER may be associated with malignant arrhythmias. Validation of this hypothesis was provided by recent studies demonstrating that an ER pattern in the inferior or inferolateral leads is associated with increased risk for life-threatening arrhythmias, termed ER syndrome (ERS). Because accentuated J waves characterize both Brugada syndrome (BS) and ERS, these syndromes have been grouped under the term "J wave syndromes". ERS and BS share similar ECG characteristics, clinical outcomes and risk factors, as well as a common arrhythmic platform related to amplification of I_to-mediated J waves. Although BS and ERS differ with respect to the magnitude and lead location of abnormal J wave manifestation, they can be considered to represent a continuous spectrum of phenotypic expression. Although most subjects exhibiting an ER pattern are at minimal to no risk, mounting evidence suggests that careful attention should be paid to subjects with "high risk" ER. The challenge ahead is to be able to identify those at risk for sudden cardiac death. Here I review the clinical and genetic aspects as well as the cellular and molecular mechanisms underlying the J wave syndromes. (Circ J 2012; 76: 1054-1065)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 76 (5), 1054-1065, 2012

  一般社団法人 日本循環器学会

キーワード

• Brugada syndrome
• Cardiac arrhythmias
• Early repolarization syndrome
• Idiopathic ventricular fibrillation
• Sudden cardiac death

詳細情報

• CRID: 1390282680079511168
• NII論文ID: 10030131896
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-12-0284
• COI: 1:STN:280:DC%2BC38rksF2itA%3D%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 22498570
• Web Site: https://www.jstage.jst.go.jp/article/circj/76/5/76_CJ-12-0284/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013106699
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
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