Cardioprotection from ischemia/reperfusion injury: basic and translational research

• Minamino Tetsuo

  Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

書誌事項

タイトル別名

• Cardioprotection From Ischemia/Reperfusion Injury
• – Basic and Translational Research –

抄録

Because ischemic heart diseases (IHDs) are a major cause of mortality and heart failure, novel therapeutic approaches are expected to improve the clinical outcomes of patients with IHDs such as acute myocardial infarction and ischemic heart failure. Brief episodes of nonlethal ischemia and reperfusion before sustained ischemia or at the onset of reperfusion can reduce ischemia-reperfusion injury. These ischemic conditioning phenomena are termed "ischemic preconditioning" and "ischemic postconditioning", respectively. Furthermore, brief episodes of nonlethal ischemia and reperfusion applied to the organ or tissue distal to the heart reduce myocardial infarct size, known as "remote ischemic conditioning". The cardioprotection afforded by these ischemic conditionings can be used to treat patients with acute myocardial infarction or cardiac operations. Extensive research has determined that autacoids (eg, adenosine, bradykinin opioid) and cytokines, their respective receptors, kinase signaling pathways and mitochondrial modulation are involved in ischemic conditioning. Modification of these factors by pharmacological agents mimics the cardioprotection by ischemic conditioning and provides a novel therapeutic intervention for IHDs. Here, the potential mechanisms of ischemic conditioning and its "proof-of-concept" translational studies are reviewed. In the near future, large, multicenter, randomized, placebo-controlled, clinical trials will be required to determine whether pharmacological and ischemic conditioning can improve the clinical outcomes of patients with IHDs. (Circ J 2012; 76: 1074-1082)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 76 (5), 1074-1082, 2012

  一般社団法人 日本循環器学会

キーワード

• Pharmacological conditioning
• Postconditioning
• Preconditioning
• Proof-of-concept clinical studies
• Remote conditioning

詳細情報

• CRID: 1390001205102767104
• NII論文ID: 10030132082
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-12-0132
• COI: 1:CAS:528:DC%2BC38Xns12jtbo%3D
• ISSN: 13474820
• ISSN: 13469843
• PubMed: 22504127
• Web Site: https://www.jstage.jst.go.jp/article/circj/76/5/76_CJ-12-0132/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013106701
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
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