-
- Kulvietis Vytautas
- Biomedical Physics Laboratory, Institute of Oncology, Vilnius University Biophotonics group of Laser Research Center, Faculty of Physics, Vilnius University
-
- Zalgeviciene Violeta
- Faculty of Medicine, Vilnius University
-
- Didziapetriene Janina
- Biomedical Physics Laboratory, Institute of Oncology, Vilnius University Faculty of Medicine, Vilnius University
-
- Rotomskis Ricardas
- Biomedical Physics Laboratory, Institute of Oncology, Vilnius University Biophotonics group of Laser Research Center, Faculty of Physics, Vilnius University
この論文をさがす
抄録
Nanoparticles (NP) are organic or inorganic substances, the size of which ranges from 1 to 100 nm, and they possess specific properties which are different from those of the bulk materials in the macroscopic scale. In a recent decade, NP were widely applied in biomedicine as potential probes for imaging, drug-delivery systems and regenerative medicine. However, rapid development of nanotechnologies and their applications in clinical research have raised concerns about the adverse effects of NP on human health and environment. In the present review, special attention is paid to the fetal exposure to NP during the period of pregnancy. The ability to control the beneficial effects of NP and to avoid toxicity during treatment requires comprehensive knowledge about the distribution of NP in maternal body and possible penetration through the maternal-fetal barrier that might impair the embryogenesis. The initial in vivo and ex vivo studies imply that NP are able to cross the placental barrier, but the passage to the fetus depends on the size and the surface coating of NP as well as on the experimental model. The toxicity assays indicate that NP might induce adverse physiological effects and impede embryogenesis. The molecular transport mechanisms which are responsible for the transport of nanomaterials across the placental barrier are still poorly understood, and there is a high need for further studies in order to resolve the NP distribution patterns in the organism and to control the beneficial effects of NP applications during pregnancy without impeding the embryogenesis.
収録刊行物
-
- The Tohoku Journal of Experimental Medicine
-
The Tohoku Journal of Experimental Medicine 225 (4), 225-234, 2011
東北ジャーナル刊行会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679221125248
-
- NII論文ID
- 130004459941
- 10030196291
-
- NII書誌ID
- AA00863920
-
- ISSN
- 13493329
- 00408727
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可