Systemic Follicular Lymphoma with Massive Intestinal Involvement with Leukemic Manifestation
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- Ono Yuichiro
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Aoki Kazunari
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Kato Aiko
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Arima Hiroshi
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Takiuchi Yohko
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Nagano Seiji
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Tabata Sumie
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Yanagita Sohshi
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Matsushita Akiko
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Maruoka Hayato
- Laboratory Medicine, Kobe City Medical Center General Hospital
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- Imai Yukihiro
- Clinical Pathology Kobe City Medical Center General Hospital
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- Ishikawa Takayuki
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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- Takahashi Takayuki
- Departments of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital
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A 30-year-old man was referred to our hospital with leukocytosis and fecal occult blood. His white blood cell count was 30.2 × 109/L with 79% small- to medium-sized lymphocytes. Surface antigen analysis revealed that these lymphocytes were positive for CD19, CD20, CD10, and CD23, but negative for CD5. The lymphocytes infiltrated the bone marrow. On endoscopic examination of the duodenum and jejunum, many small polypoid lesions were observed. A histologic picture of a biopsied lesion showed diffuse infiltration of small- to medium-sized lymphocytes in the submucosal region. On immunohistochemistry, these lymphocytes were positive for CD20, BCL2, and CD10 (weakly). Polymerase chain reaction analysis of cells from peripheral blood, bone marrow, and intestinal lesion showed a fusion product of BCL2 and immunoglobulin heavy chain (IGH) genes. The fused BCL2/IGH gene was also demonstrated by fluorescence in situ hybridization in the same cell sources. Computed tomography scanning showed marked wall thickening throughout the small intestine and enlarged mesenteric lymph nodes. A diagnosis of follicular lymphoma with massive intestinal involvement in a leukemic state was made. After 6 courses of rituximab-combined CHOP chemotherapy, complete remission was obtained. [J Clin Exp Hematopathol 51(2) : 135-140, 2011]
収録刊行物
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 51 (2), 135-140, 2011
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詳細情報 詳細情報について
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- CRID
- 1390282679679898624
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- NII論文ID
- 10030207699
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- NII書誌ID
- AA11556796
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- ISSN
- 18809952
- 13464280
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可