造血幹細胞移植後に上顎へ髄外再発した急性リンパ性白血病の1例

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  • Isolated extramedullary relapse of acute lymphocytic leukemia in the maxilla after allogeneic stem cell transplantation
  • ゾウケツ カン サイボウ イショク ゴ ニ ウワアゴ エ ズイガイ サイハツ シタ キュウセイ リンパセイ ハッケツビョウ ノ 1レイ

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We report a case of extramedullary relapse of acute lymphocytic leukemia （ALL） in the maxilla of 22-year-old man after an allogeneic stem cell transplantation. Relapse of ALL usually occurs in either the central nerve system or a testis because these organs are independent of systemic immunity. A complete remission had been achieved temporarily by both induction chemotherapy and stem cell transplantation. One year after transplantation, a relapse occurred with an extramedullary mass in the right side of the maxilla. The patient received chemotherapy and local radiation therapy of the mass because the bone marrow was not involved. Bone marrow relapse occurred about 6 months after the extramedullary relapse. Unfortunately, the patient died of sepsis during re-induction therapy. This case is the first domestic report of an isolated extramedullary relapse of ALL in the maxilla after allogeneic stem cell transplantation.

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