INTEGRATED PAPER : Ionic Probe Attachment Ionization Mass Spectrometry

• ITO Fumihiro

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• ANDO Shin

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• IUCHI Masato

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• UKARI Taki

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• TAKASAKI Momoka

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• NAKAMURA Tomoko

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• YORITA Satoko

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

• YAMAGUCHI Kentaro

  Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University

書誌事項

タイトル別名

• Ionic Probe Attachment Ionization Mass Spectrometry

抄録

We have developed a new ionization method that uses metal-complex-based ionization probes containing the 2,6-bis(oxazolinyl)pyridine (pybox) ligand, NHS-TMpybox, Mal-TMpybox, BrAc-TMpybox, oxime-TMpybox, and Sar-TMpybox. NHS-TMpybox, Mal-TMpybox, BrAc-TMpybox, and oxime-TMpybox were reacted selectively with the functional groups of biomolecules, whereas Sar-TMpybox was reacted with carbon clusters. These were able to obtain multiply charged ions of target molecules. This method was proven to effectively ionize large complex molecules, including biomolecules and various supramolecules, as well as carbon clusters, such as fullerenes. Moreover, isotope-labeled pybox-La complexes were used to clearly detect isotopic labeling shifts. Their applications to multiply charged ionization, including isotope labeling of biomolecules and carbon clusters using cold-spray ionization mass spectrometry (CSI-MS), are shown.

収録刊行物

• 質量分析

  質量分析 60 (1), 5-12, 2012

  一般社団法人 日本質量分析学会

キーワード

• Ionic probe
• Cold spray ionization
• Isotope labeling
• Mass tag

詳細情報

• CRID: 1390001206496615552
• NII論文ID: 10030286490
• NII書誌ID: AN0010555X
• DOI: 10.5702/massspec.11-32
• ISSN: 18804225
• ISSN: 18843271
• ISSN: 13408097
• NDL書誌ID: 023517970
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I023517970
• Web Site: http://www.jstage.jst.go.jp/article/massspec/60/1/60_11-32/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可