IDIOPATHIC MESENTERIC PHLEBOSCLEROSIS : ITS CLINICO-PHATHOLOGICAL FEATURES AND DIFFERENTIAL DIAGNOSIS

DOI 108 References
  • YAO Takashi
    Department of Human Pathology, Juntendo University School of Medicine.
  • HIRAHASHI Minako
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University.

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  • 特発性腸間膜静脈硬化症の病態と鑑別診断

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Abstract

Idiopathic mesenteric phlebosclerosis is a relatively rare disease, however, it has now been established as a single disease entity. Clinically it is characterized by the average age in the 6th decade, a slightly higher prevalence in women, affecting only Asian patients (especially Japanese), and right-sided colon predominance. Calcification along the intestinal wall in plain abdominal X-ray images, and calcification along the mesenteric veins in CT scans are characteristic features. Histologically, perivascular collagen deposition, marked submucosal fibrosis and calcification in the veins are characteristic features, accompanied by minimal inflammation except for areas of erosion. Clinically, conservative management is common for asymptomatic patients and, surgical resection is generally accepted for the patients with stenosis, ulcers of the colon or other such symptoms. The cause of idiopathic mesenteric phlebosclerosis still remains unknown, however Chinese medicine, including some toxic agents, has been attracting attention as a factor in the development of idiopathic mesenteric phlebosclerosis. In the future, it is expected that preventive measure will be established by elucidating its cause.

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