Effect of Minocycline on Inflammatory Cell Reactions in Cerebral Contusion in Rats

DOI Web Site Web Site 参考文献57件
  • Sawamoto Atsushi
    Department of Functional Morphology, Nihon University School of Medicine
  • Koshinaga Morimichi
    Department of Functional Morphology, Nihon University School of Medicine
  • Oshima Hideki
    Department of Functional Morphology, Nihon University School of Medicine Neurological Surgery, Nihon University School of Medicine
  • Harada Tomonori
    Department of Functional Morphology, Nihon University School of Medicine
  • Tsuboi Isao
    Department of Functional Morphology, Nihon University School of Medicine
  • Aizawa Shin
    Department of Functional Morphology, Nihon University School of Medicine

この論文をさがす

抄録

Following traumatic brain injury (TBI), inflammatory cells including activated microglia and blood-derived leukocytes, infiltrate into the contusion, and the subsequent inflammatory response may contribute to secondary degenerative brain damage. Thus, treatment strategies designed to inhibit the secondary inflammatory response may be of value in the treatment of TBI patients. Therapeutically, the beneficial effects of minocycline, a derivative of the antibiotic tetracycline, have been shown in various models of central nervous system disorders through inhibition of the inflammatory reactions. This study investigated whether minocycline could ameliorate traumatic brain injury in a rat model. The inflammatory reaction, as represented by morphological changes in microglia and the infiltration of macrophages, persisted for 2 weeks after induction of a controlled cortical impact (CCI) injury. Thus, post CCI, the rats were treated with minocycline or vehicle intraperitoneally every 24 hours until sacrifice at 2 weeks, and the infiltration of inflammatory cells into the contusion, and the lesion size were measured.

収録刊行物

参考文献 (57)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ