Hyperbolic correlation between insulin sensitivity and insulin secretion fades away in lean subjects with superb glucose regulation

• Aizawa Toru

  Diabetes Center, Aizawa Hospital, Matsumoto, Japan

• Yamada Masayuki

  Clinical Biometrics, Planning and Managing Department, Kissei Pharmaceutical Co., Ltd., Tokyo, Japan

• Katakura Masafumi

  Department of Medicine, Chikuma Central Hospital, Chikuma, Japan

• Funase Yoshiko

  Diabetes Center, Aizawa Hospital, Matsumoto, Japan

• Yamashita Koh

  Diabetes Center, Aizawa Hospital, Matsumoto, Japan

• Yamauchi Keishi

  Diabetes Center, Aizawa Hospital, Matsumoto, Japan

抄録

The relationship between insulin sensitivity (Si) and insulin secretion (β) was analyzed in 533 health examinees. The subjects underwent a 75 g oral glucose tolerance test, with plasma glucose (PG) and immunoreactive insulin (IRI) determined at fasting, 30 min and 120 min, and were classified according to the current criteria as normal glucose tolerance (NGT, n=328), non-diabetic hyperglycemia (NDH, n=113) including impaired fasting glucose and impaired glucose tolerance, and diabetes mellitus (DM, n=72). NGT was subdivided by fasting PG (FPG) tertile, ≤4.9, 5.0-5.4 and 5.5-6.0 mM, into NGT_FPG1, NGT_FPG2 and NGT_FPG3, or by body mass index (BMI) tertile, ≤21.8, 21.9-24.4 and ≥24.5 kg/m², into NGT_BMI1, NGT_BMI2 and NGT_BMI3. As an index of Si and β, Matsuda index=10,000/sqrt[FPG·FIRI·2hPG·2hIRI] and δIRI_0-30/δPG_0-30, were employed respectively: FIRI, 2hPG and 2hIRI denote fasting IRI, 2h-post glucose PG and IRI, respectively. Correlation between Si and β was evaluated by Spearman’s rank correlation and the parameters for [β]=a·[Si]^b were obtained by standardized major axis (SMA) regression. Si-β correlation was strongest in NDH (Spearman’s rho=-0.546, SMA regression r²=0.277), intermediate in DM (rho=-0.432, r²=0.193) and weakest in NGT (rho=-0.201, r²=0.039). Spearman’s rho for the Si-β correlation was significantly lower in NGT than in NDH (p=0.003). Si-β correlation was significant in NGT_FPG3, NGT_FPG2 and NGT_BMI3, but not in NGT_FPG1, NGT_BMI2 and NGT_BMI1. The slope, b, was -1.184˜-1.530 without significant differences between any groups. In conclusion, the hyperbolic Si-β correlation was weaker in NGT than in NDH and absent in NGT subjects belonging to the lowest FPG or BMI tertile.

収録刊行物

• Endocrine Journal

  Endocrine Journal 59 (2), 127-136, 2012

  一般社団法人 日本内分泌学会

キーワード

• Beta cell function
• Insulin sensitivity
• Hyperbolic law
• Glucose tolerance

詳細情報

• CRID: 1390282681277059840
• NII論文ID: 10030393172
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.ej11-0162
• COI: 1:STN:280:DC%2BC383mvFWmtg%3D%3D
• ISSN: 13484540
• ISSN: 09188959
• PubMed: 22094999
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/59/2/59_EJ11-0162/_pdf
• 本文言語コード: en
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