A case of angioimmunoblastic T-cell lymphoma with bone marrow involvement, polyclonal hypergammaglobulinemia and skin rash

• SUZUKI Norihiro

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• SUZUKI Daisuke

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• FUJITA Atsushi

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• NOMURA Chiyo

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• FUJII Kazuyasu

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• TSUJI Kazuhide

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• YAMASAKI Osamu

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• ONO Takashi

  <i>Department of Dermatology, Okayama University School of Medicine</i>

• IWATSUKI Keiji

  <i>Department of Dermatology, Okayama University School of Medicine</i>

Bibliographic Information

Other Title

• 中毒疹様皮疹，多クローン性高ガンマグロブリン血症，骨髄浸潤を伴ったangioimmunoblastic T－cell lymphomaの1例

Abstract

An 85-year-old man presented with a one-month history of generalized skin rash associated with continuous low-grade fever and sweating at night. A skin biopsy specimen showed a nonspecific finding of perivascular dermatitis. Laboratory findings revealed mild anemia, polyclonal hypergammaglobulinemia, and elevated levels of C-reactive protein, erythrocyte sedimentation rate and soluble interleukin-2 receptor. No serological abnormalities were found for HTLV-1 or EBV. Computed tomography findings showed generalized lymphadenopathy and mild splenomegaly. Histological findings of the inguinal lymph node showed destructive proliferation of CD4 and CD45RO positive atypical medium-sized lymphocytes associated with angiogenesis. Southern blot analysis detected a clonal rearrangement of T-cell receptor Cβ1 genes. Bone marrow aspiration revealed infiltration of lymphocytes with the same phenotype as those of the tumor cells in the lymph node. Based on these findings, a diagnosis of angioimmunoblastic T-cell lymphoma with bone marrow involvement (stage IV) was made.[Skin Cancer (Japan) 2011 ; 26 : 134-138]

Journal

• Skin Cancer

  Skin Cancer 26 (2), 134-138, 2011

  The Japanese Skin Cancer Society

Keywords

• Angioimmunoblastic T-cell lymphoma
• Bone marrow involvement
• Pancytopenia
• Skin rash
• EB-virus

Details

• CRID: 1390001204335538432
• NII Article ID: 10030441944
• NII Book ID: AN10087647
• DOI: 10.5227/skincancer.26.134
• ISSN: 18843549
• ISSN: 09153535
• Web Site: https://search.jamas.or.jp/link/ui/2012038267
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed