Virucidal Activity of Alcohol-Based Hnd Rub Disinfectants

• IWASAWA ATSUO

  Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

• NIWANO YOSHIMI

  Laboratory for Redox Regulation, Tohoku University Graduate School of Dentistry

• KOHNO MASAHIRO

  Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

• AYAKI MASAHIKO

  Department of Ophthalmology, Saitama National Hospital

書誌事項

タイトル別名

• Virucidal Activity of Alcohol-Based Hand Rub Disinfectants

抄録

  We investigated the virucidal activity of commercially available alcohol-based hand rub products against coxsackievirus A7, B5, feline calicivirus F9, and human adenovirus type 3, type 7, type 8 using susceptible cell lines, Vero cells, CRFK cells, and A549 cells. Fifteen tested hand rub products were ethanol (EtOH) for disinfection (Japanese Pharmacopoeia Grade), two EtOH-based products, one povidone iode-containing product, one alkyldiaminoethylglycine hydrochloride-containing product, six benzalkonium chloride (BAK)-containing products, and four chlorohexidine gluconate (CHG)-containing products. Some active ingredients (BAK, benzetonium chloride, and CHG) were diluted with EtOH to make 0.5% and 0.2% solutions. Virus inactivation rates were calculated after contact with each hand rub product for 10 or 60 seconds. Of the hand rub products tested, only the povidone iode-based product showed antiviral activity superior to that of EtOH against all the strains. EtOH solutions of active ingredients (0.2% and 0.5%) also showed decreased antiviral activity. In conclusion, antiviral activity of all the commercially available alcohol-based hand rub products except that containing povidone idode was dependent on their active ingredients. The povidone idode-containing hand rub product kept its effectiveness even after the dilution with EtOH. Although alcohol-based hand rub products are convenient and suitable for the control of some microbes, they are not generally recommended for the control of viral infections.

収録刊行物

• Ｂｉｏｃｏｎｔｒｏｌ　Ｓｃｉｅｎｃｅ

  Ｂｉｏｃｏｎｔｒｏｌ　Ｓｃｉｅｎｃｅ 17 (1), 45-49, 2012

  日本防菌防黴学会

キーワード

• Virucidal activity
• Alcohol based hand rub
• Coxsackie virus
• Feline calicivirus
• Human adenovirus

詳細情報

• CRID: 1390282679440997760
• NII論文ID: 10030447967
• NII書誌ID: AA11169621
• DOI: 10.4265/bio.17.45
• COI: 1:CAS:528:DC%2BC38Xls1altLk%3D
• ISSN: 18840205
• ISSN: 13424815
• PubMed: 22451431
• Web Site: https://search.jamas.or.jp/link/ui/2013012409
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可