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- 森尾 友宏
- 東京医科歯科大学大学院発生発達病態学分野
書誌事項
- タイトル別名
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- Common variable immunodeficiency: an update on etiology, pathophysiology, and classification
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抄録
Common variable immunodeficiency is one of the most common primary immunodeficiency that is categorized into primary antibody deficiency. The responsible genes identified so far include ICOS, TACI, CD19, CD20, CD21, CD81 and BAFF-R; and most of the CVID-causing genes are yet to be identified. TACI mutation is the most common one; however the direct contribution of TACI mutation to pathogenesis of CVID is not yet clear. One third to a half of the patients with CVID shows autoimmunity as well as malignancy in their course. It is of importance to develop diagnostic measure, to identify the disease causing genes, and to develop the optimal therapy.<br>
収録刊行物
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- 日本臨床免疫学会会誌
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日本臨床免疫学会会誌 35 (1), 14-22, 2012
日本臨床免疫学会
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詳細情報 詳細情報について
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- CRID
- 1390001204652564480
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- NII論文ID
- 10030465505
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- NII書誌ID
- AN00357971
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- COI
- 1:CAS:528:DC%2BC38XltFynt7c%3D
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- ISSN
- 13497413
- 09114300
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- PubMed
- 22374438
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- データソース種別
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- JaLC
- Crossref
- PubMed
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- 抄録ライセンスフラグ
- 使用不可