書誌事項
- タイトル別名
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- Crucial role of TNFα-induced adipose-related protein (TIARP) in the pathogenesis of autoimmune arthritis
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Rheumatoid arthritis (RA) is a chronic inflammatory disorder with a variable disease outcome, and is characterized by inflammation of multiple joints. Proinflammtory cytokines, such as tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6) are thought to play crucial roles in the pathology of RA. The prognosis of patients with RA has improved significantly with the recent availability of biologics targeting TNFα and IL-6. Immunization of DBA/1 mice with glucose-6-phosphate isomerase (GPI) induces severe acute arthritis. This arthritis can be controlled by TNFα antagonists, suggesting similar etiology to RA. We performed GeneChip analysis using splenocytes of mice with GPI-induced arthritis. Among the arrayed TNFα-related genes, the expression of TNFα-induced adipose-related protein (TIARP) mRNA was the highest. TIARP was detected specifically in joints and spleens of arthritic mice. Among the splenocytes, CD11b+ cells were the main source of TIARP mRNA. STEAP4 (the human ortholog of TIARP) was highly upregulated in joints of patients with RA and especially co-localized with CD68+ macrophages. In this study, we discuss the role of TIARP in the generation of experimental autoimmune arthritis and the possible clinical application of for the treatment of RA.<br>
収録刊行物
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- 日本臨床免疫学会会誌
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日本臨床免疫学会会誌 35 (1), 51-55, 2012
日本臨床免疫学会
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詳細情報 詳細情報について
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- CRID
- 1390282679629282048
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- NII論文ID
- 10030465623
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- NII書誌ID
- AN00357971
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- COI
- 1:CAS:528:DC%2BC38XltFyntb4%3D
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- ISSN
- 13497413
- 09114300
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- PubMed
- 22374443
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