Osteoblast compatibility of materials depends on serum protein absorbability in osteogenesis

• HARIMOTO Kenichi

  Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

• YOSHIDA Yasuhiro

  Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• YOSHIHARA Kumiko

  Leuven BIOMAT Research Cluster, Department of Conservative Dentistry, Catholic University of Leuven

• NAGAOKA Noriyuki

  Laboratory for Electron Microscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• MATSUMOTO Takuya

  Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• TAGAWA Yoh-ichi

  Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology

抄録

Titanium has an osseointegrative property, while hydroxyapatite has an osteoconductive property. It remains a matter of controversy among researchers whether hydroxyapatite has higher osteoblast compatibility than titanium. Here, we compared the activities between osteoblasts cultured on titanium and those cultured on hydroxyapatite. An osteoblast-like cell line, MC3T3-E1, was cultured on machined titanium, evaporated titanium, and hydroxyapatite disks to compare the affinity of osteoblasts to each of these materials. The adhesion and proliferation of MC3T3-E1 cells were higher on hydroxyapatite disks than on the other disks. Osteoblast differentiation was not affected by the nature of disks investigated, but calcium was more easily deposited on the hydroxyapatite disks. The amount of absorbed serum proteins detected on hydroxyapatite was greater than that on titanium. In conclusion, our results indicate hydroxyapatite is a more suitable material for osteoblast growth than titanium because of its higher absorption of serum proteins.

収録刊行物

• Dental Materials Journal

  Dental Materials Journal 31 (4), 674-680, 2012

  一般社団法人　日本歯科理工学会

キーワード

• Osteoblast
• Hydroxyapatite
• Titanium

詳細情報

• CRID: 1390282679693455232
• NII論文ID: 10030501890
• NII書誌ID: AA10443149
• DOI: 10.4012/dmj.2012-075
• COI: 1:STN:280:DC%2BC38flsFKntg%3D%3D
• ISSN: 18811361
• ISSN: 02874547
• PubMed: 22864224
• Web Site: https://www.jstage.jst.go.jp/article/dmj/31/4/31_2012-075/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013357164
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可