Prevalence of Inherited Thrombophilia in Patients With Documented Stent Thrombosis

DOI Web Site PubMed 参考文献30件
  • Zavalloni Dennis
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Presbitero Patrizia
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Lodigiani Corrado
    Thrombosis Center, Humanitas Clinical Institute Thrombosis Center, Humanitas Clinical Institute
  • Mango Ruggiero
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Cogliati Tommaso
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Quaglia Ilaria
    Thrombosis Center, Humanitas Clinical Institute Thrombosis Center, Humanitas Clinical Institute
  • Corrada Elena
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Mendolicchio Grazia-Loredana
    Thrombosis Center, Humanitas Clinical Institute Thrombosis Center, Humanitas Clinical Institute
  • Gasparini Gabriele-Luigi
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Rossi Marco-Luciano
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Ferrazzi Paola
    Thrombosis Center, Humanitas Clinical Institute Thrombosis Center, Humanitas Clinical Institute
  • Belli Guido
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Pagnotta Paolo
    Invasive Cardiology Department, Humanitas Clinical Institute Invasive Cardiology Department, Humanitas Clinical Institute
  • Rota Lidia-Luciana
    Thrombosis Center, Humanitas Clinical Institute Thrombosis Center, Humanitas Clinical Institute

この論文をさがす

抄録

Background: Stent thrombosis (ST) is a multi-factorial process involving different mechanisms. The impact of inherited coagulation disorders in the genesis of ST has never been assessed. The aim of the present study was to evaluate the prevalence of G1691A Factor V Leiden mutation, G20210A Factor II (prothrombin) mutation and C677T homozygous methylenetetrahydrofolate reductase (MTHFR) polymorphism in patients with ST. Methods and Results: The prevalence of the aforementioned gene variations was assessed in 127 patients: 50 admitted for ST and 77 previously treated with percutaneous coronary intervention not developing ST. A control cohort of 529 healthy volunteers was sampled from the same geographical area. Patients with ST were carriers of at least 1 gene variation in 28% of cases. The prevalence of G1691A Factor V Leiden mutation (odds ratio [OR]=0.64; 95% confidence interval [CI]: 0.04-10.5), G20210A Factor II mutation (OR=0.63; 95% CI: 0.12-3.28) and C677T MTHFR homozygous polymorphism (OR=1.13; 95% CI: 0.47-2.72) did not differ significantly among patients with or without ST. The logistic regression model did not show a significant association between gene variations and ST (OR=0.61; 95% CI: 0.24-1.60; P=0.32). Conclusions: A specific association between studied gene variations and ST has not been detected. The relatively high prevalence of at least 1 gene anomaly in such a rare subset of patients, and its consequences in term of secondary prevention therapy, suggests that screening for thrombophilia might be justifiable in cases of ST.  (Circ J 2012; 76: 1874–1879)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 76 (8), 1874-1879, 2012

    一般社団法人 日本循環器学会

参考文献 (30)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ