Clinical Efficacy of Cardiac Resynchronization Therapy With an Implantable Defibrillator in a Japanese Population
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- Momomura Shin-ichi
- Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University
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- Tsutsui Hiroyuki
- Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
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- Sugawara Yoshitaka
- Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University
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- Ito Makoto
- Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science
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- Mitsuhashi Takeshi
- Department of Cardiovascular Medicine, Jichi Medical University Department of Cardiovascular Medicine, Jichi Medical University
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- Fukamizu Seiji
- Department of Cardiology, Tokyo Metropolitan Hiroo Hospital Department of Cardiology, Tokyo Metropolitan Hiroo Hospital
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- Noro Mahito
- Division of Cardiovascular Medicine, Toho University Ohashi Medical Center Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
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- Matsumoto Naoki
- Department of Pharmacology, St. Marianna University School of Medicine Department of Pharmacology, St. Marianna University School of Medicine
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- Tejima Tomoyuki
- Cardiac Rhythm Disease Management, Medtronic Japan Co, Ltd Cardiac Rhythm Disease Management, Medtronic Japan Co, Ltd
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- Sugi Kaoru
- Division of Cardiovascular Medicine, Toho University Ohashi Medical Center Division of Cardiovascular Medicine, Toho University Ohashi Medical Center
書誌事項
- タイトル別名
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- – Results of the MIRACLE-ICD Outcome Measured in Japanese Indication (MOMIJI) Study –
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Background: Cardiac resynchronization therapy (CRT) is effective in reducing morbidity and mortality in systolic heart failure patients with cardiac dyssynchrony as demonstrated in studies with primarily Western populations. Although CRT devices with a defibrillator (CRT-D) became available in Japan since 2006, their efficacy remains uncertain in Japanese patients. In this prospective, multicenter study, the efficacy of CRT-D therapy in an all-Japanese population was compared with the study conducted in the US, Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE-ICD). Methods and Results: Ninety-three patients were evaluated according to the subject selection criteria of the MIRACLE-ICD study, and 80 patients were enrolled. Results at baseline and 6-month post-CRT-D implantation were compared in terms of composite clinical response (CCR) and other secondary endpoints. Quality of life (QOL) was assessed with a validated Japanese version of the Minnesota Living with Heart Failure questionnaire. CCR was improved in 55 patients (68.8%), unchanged in 14 (17.5%), and worsened in 11 patients (13.7%) (MIRACLE-ICD general phase: 62.0%, 13.4% and 24.6%, respectively). Non-inferiority was verified by 1-sided test with 10% equivalence margin. QOL score improved significantly (50.0±26.2 vs. 23.6±20.2, P<0.01). Conclusions: The MOMIJI study demonstrated that CRT-D effectiveness as assessed with CCR was non-inferior to the trials conducted outside Japan, thus suggesting that the benefits of CRT-D are similar between Japanese and non-Japanese patients. (Circ J 2012; 76: 1911–1919)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 76 (8), 1911-1919, 2012
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680078861952
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- NII論文ID
- 10030504546
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BC38noslOrug%3D%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 22664486
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- PubMed
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