Impact of Metabolic Syndrome on Various Aspects of Microcirculation and Major Adverse Cardiac Events in Patients With ST-Segment Elevation Myocardial Infarction
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- Uchida Yasuhiro
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Ichimiya Satoshi
- Department of Cardiology, Yokkaichi Municipal Hospital
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- Ishii Hideki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Kanashiro Masaaki
- Department of Cardiology, Yokkaichi Municipal Hospital
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- Watanabe Junji
- Department of Cardiology, Yokkaichi Municipal Hospital
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- Yoshikawa Daiji
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Takeshita Kyosuke
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Sakai Shinichi
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Amano Tetsuya
- Department of Cardiology, Aichi Medical University School of Medicine
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- Matsubara Tatsuaki
- Department of Internal Medicine, School of Dentistry Aichi Gakuin University
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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Background: Microvascular impairment is associated with a poor prognosis even after successful percutaneous coronary intervention (PCI) in acute myocardial infarction. The aim of the present study was to examine the impact of metabolic syndrome (MetS) on various aspects of microvascular function and clinical outcomes. Methods and Results: In 216 consecutive patients with ST-segment elevation myocardial infarction (STEMI) after successful primary PCI, data were collected and analyzed on epicardial coronary flow, ST-segment resolution (STR) on electrocardiography, maximum serum creatine kinase levels, and the incidence of major adverse cardiac events (MACE). The prevalence of MetS was 40.7% (88 patients). Corrected Thrombolysis In Myocardial Infarction frame count was significantly higher in the MetS group than in the non-MetS group (28.1±9.4 vs. 24.7±7.9, P=0.04). STR ≥50% was observed in 51.1% and 69.5%, respectively (P=0.01). Patients with MetS also had higher maximum creatine kinase levels (3,470±2,320IU/L vs. 2,664±1,850IU/L, P=0.01). On logistic regression analysis after adjustment for confounders, MetS was an independent negative predictor of complete STR (odds ratio, 0.49; 95% confidence interval [CI]: 0.25-0.95, P=0.03). On Cox multivariate analysis, MetS was an independent predictor for MACE (hazard ratio, 4.85; 95% CI: 1.28-18.3, P=0.02). Conclusions: MetS may damage microcirculation after direct PCI in patients with STEMI and lead to poor prognosis. (Circ J 2012; 76: 1972–1979)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 76 (8), 1972-1979, 2012
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390282680078859776
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- NII論文ID
- 10030504885
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BC38novVahtA%3D%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 22664935
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- PubMed
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- 使用不可