Effects of Cumulative Smoking Exposure and Duration of Smoking Cessation on Carotid Artery Structure

DOI Web Site PubMed 被引用文献4件 参考文献27件
  • Kweon Sun-Seog
    Department of Preventive Medicine, Chonnam National University Medical School Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital Department of Preventive Medicine, Chonnam National University Medical School Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital
  • Lee Young-Hoon
    Department of Preventive Medicine, Wonkwang University College of Medicine Institute of Wonkwang Medical Science Department of Preventive Medicine, Wonkwang University College of Medicine Institute of Wonkwang Medical Science
  • Shin Min-Ho
    Department of Preventive Medicine, Chonnam National University Medical School Department of Preventive Medicine, Chonnam National University Medical School
  • Choi Jin-Su
    Department of Preventive Medicine, Chonnam National University Medical School Department of Preventive Medicine, Chonnam National University Medical School
  • Rhee Jung-Ae
    Department of Preventive Medicine, Chonnam National University Medical School Department of Preventive Medicine, Chonnam National University Medical School
  • Choi Seong-Woo
    Department of Preventive Medicine, Chosun University Medical School Department of Preventive Medicine, Chosun University Medical School
  • Ryu So-Yeon
    Department of Preventive Medicine, Chosun University Medical School Department of Preventive Medicine, Chosun University Medical School
  • Kim Bok-Hee
    Department of Food & Nutrition, Chosun University College of Natural Sciences Department of Food & Nutrition, Chosun University College of Natural Sciences
  • Nam Hae-Sung
    Department of Preventive Medicine, Chungnam National University College of Medicine Department of Preventive Medicine, Chungnam National University College of Medicine
  • Jeong Seul-Ki
    Department of Neurology, Chonbuk National University Medical School and Hospital Department of Neurology, Chonbuk National University Medical School and Hospital
  • Park Kyeong-Soo
    Department of Preventive Medicine, Seonam University College of Medicine Department of Preventive Medicine, Seonam University College of Medicine

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Background: While prior epidemiological studies have examined the association between cigarette smoking and carotid atherosclerosis, few studies have evaluated the association of both cumulative smoking exposure and the duration of smoking cessation with carotid artery structure. Methods and Results: The study population consisted of 2,503 community-dwelling Korean males aged 50 years and older. Common carotid artery intima-media thickness (CCA-IMT), carotid plaque, and the internal diameter of the common carotid artery (CCA-diameter) were determined by high-resolution B-mode ultrasonography. Data on the characteristics of the subjects, including smoking status, pack-years of smoking, and years since quitting smoking, were collected using a standardized questionnaire. The current smokers had significantly greater CCA-IMT and CCA-diameter and a significantly higher risk of carotid plaque than did the subjects who had never smoked (P=0.009, <0.001, and 0.036, respectively). Dose-response relationships between pack-years and CCA-IMT and CCA-diameter were found among the current smokers (P=0.001 and <0.001, respectively); however, no significant association between pack-years and the carotid artery parameters was observed among the former smokers. For the former smokers, CCA-IMT and CCA-diameter tended to decrease with increasing years since quitting smoking (P=0.009 and 0.012, respectively), whereas no significant association with carotid plaque was found. Conclusions: Cumulative smoking exposure in current smokers and the duration of smoking cessation in former smokers are significant risk factors for carotid atherosclerosis.  (Circ J 2012; 76: 2041–2047)<br>

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  • Circulation Journal

    Circulation Journal 76 (8), 2041-2047, 2012

    一般社団法人 日本循環器学会

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