Data on Wistar Hannover Rats from an Immunotoxicity Study

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  • Yamatoya Hideyuki
    The United Graduate School of Veterinary Science, Yamaguchi University Department of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd. (SNBL DSR)
  • Kawaguchi Hiroaki
    The United Graduate School of Veterinary Science, Yamaguchi University Department of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University
  • Fukuda Takeshi
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd. (SNBL DSR)
  • Kadokura Hidetomi
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd. (SNBL DSR)
  • Yamashita Rie
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd. (SNBL DSR)
  • Yoshikawa Tsuyoshi
    Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd. (SNBL DSR)
  • Shiraishi Mitsuya
    The United Graduate School of Veterinary Science, Yamaguchi University Department of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University
  • Miyamoto Atsushi
    The United Graduate School of Veterinary Science, Yamaguchi University Department of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University
  • Miyoshi Noriaki
    The United Graduate School of Veterinary Science, Yamaguchi University Department of Veterinary Histopathology, Joint Faculty of Veterinary Medicine, Kagoshima University

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抄録

The aim of this study was to collect data on immunological parameters from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. Low leukocyte parameter cell counts, serum globulin concentration, and T, B, and NK lymphocyte counts in peripheral blood at each time point; low T, B, and NK splenocyte counts; and high, or tendencies toward high, thymocyte counts at 10 weeks of age were noted in females when compared with males. KLH-specific antibody production increased gradually with age in both sexes. The immunological data noted for leukocyte parameters, the serum globulin concentration, and immunophenotyping (peripheral blood, spleen, and thymus) relating to chronological changes and sex differences may be useful in assessing drug-related immunotoxicity in this strain.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 61 (2), 171-175, 2012

    公益社団法人 日本実験動物学会

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