Ocular Adnexal IgG4-Producing Mucosa-Associated Lymphoid Tissue Lymphoma Mimicking IgG4-Related Disease

• Sato Yasuharu

  Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

• Ohshima Koh-ichi

  Department of Ophthalmology, National Hospital Organization Okayama Medical Center

• Takata Katsuyoshi

  Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

• Huang Xingang

  Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

• Cui Wei

  Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

• Ohno Kyotaro

  Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

• Yoshino Tadashi

  Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

抄録

IgG4-related disease is a recently proposed clinical entity with several unique clinicopathological features. A chronic inflammatory state with marked fibrosis, which can often be mistaken for malignancy, especially by clinical imaging analyses, unifies these features. In the present report, we describe a case of IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease. The patient was a 55-year-old male who was being followed for right orbital tumor over 1.5 years. The lesion had recently increased in size, so a biopsy was performed. Histologically, the lesion was consistent with IgG4-related disease ; however, IgG4⁺ plasma cells showed immunoglobulin light-chain restriction and immunoglobulin heavy chain gene rearrangement was detected in the lesion. Therefore, the lesion was diagnosed as IgG4-producing mucosa-associated lymphoid tissue lymphoma. In conclusion, in histological diagnosis of IgG4-related disease, it is important to examine not only IgG4-immunostain but also immunoglobulin light-chain restriction. [J Clin Exp Hematopathol 52(1) : 51-55, 2012]

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｈｅｍａｔｏｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｈｅｍａｔｏｐａｔｈｏｌｏｇｙ 52 (1), 51-55, 2012

  日本リンパ網内系学会

キーワード

• IgG4-related disease
• IgG4-producing lymphoma
• orbital tumor

詳細情報

• CRID: 1390282679681565568
• NII論文ID: 10030615635
• NII書誌ID: AA11556796
• DOI: 10.3960/jslrt.52.51
• COI: 1:STN:280:DC%2BC38jisV2htw%3D%3D
• ISSN: 18809952
• ISSN: 13464280
• PubMed: 22706531
• Web Site: https://search.jamas.or.jp/link/ui/2013247916
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可