Analysis of candidate genes of spontaneous arthritis in mice deficient for interleukin-1 receptor antagonist
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- Cao Yanhong
- Institute of Kaschin-Beck Disease, Center for Endemic Disease Control, Centers for Disease Control and Prevention, Harbin Medical University Departments of Orthopaedic Surgery-Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC)
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- Li Caijuan
- Department of Ultrasound, Hongqi Hospital of Mudanjiang Medical University
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- Yan Jian
- Department of Medicine, University of Tennessee Health Science Center
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- Jiao Feng
- Departments of Orthopaedic Surgery-Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC)
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- Liu XiaoYun
- Departments of Orthopaedic Surgery-Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC)
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- Hasty Karen A.
- Departments of Orthopaedic Surgery-Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC)
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- Stuart John M.
- Department of Medicine, University of Tennessee Health Science Center
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- Gu Weikuan
- Departments of Orthopaedic Surgery-Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC)
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- Jiao Yan
- Departments of Orthopaedic Surgery-Campbell Clinic, and Pathology, University of Tennessee Health Science Center (UTHSC)
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抄録
Previously, we identified a major quantitative trait locus (QTL) on mouse chromosome 1 that regulates the susceptibility to arthritis in an F2 population generated from arthritis-prone BALB/c and arthritis-resistant DBA/1 mice deficient for interleukin-1 receptor antagonist. To further select candidate genes for the QTL, we analyzed the expression patterns of arthritis in 38 F2 individuals and compared the expression levels of key candidate genes to the parental strains. Two distinct subpopulations of arthritic mice were identified in the 38 F2 mice. One subgroup of diseased mice was characterized by myeloid cell dominant inflammation, whereas the other was mainly associated with increased anti-apoptotic activities of inflammatory cells. Several differentially expressed important candidate genes in parental strains in the QTL region are relevant to myeloid cell, apoptotic activities, or to both. About one-quarter of those genes have been previously linked to arthritis in literature. The present study reveals two distinct subpopulations of arthritic mice with spontaneous arthritis due to deficiency for interleukin-1 receptor antagonist, suggesting that genes with function relevant to myeloid cell and/or apoptotic activities are most likely the key candidate genes for the QTL.
収録刊行物
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- Genes & Genetic Systems
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Genes & Genetic Systems 87 (2), 107-113, 2012
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詳細情報 詳細情報について
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- CRID
- 1390282680450579840
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- NII論文ID
- 10030616593
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- NII書誌ID
- AA11077421
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- COI
- 1:STN:280:DC%2BC38fhvF2guw%3D%3D
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- ISSN
- 18805779
- 13417568
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- NDL書誌ID
- 023672962
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- PubMed
- 22820384
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可