Methionine Sulfoxide Stimulates Hepatocarcinogenesis in Non-alcoholic Steatohepatitis (NASH) Mouse: Possible Role of Free Radical-mediated DNA Methylation

DOI Web Site 被引用文献1件 参考文献55件
  • Kawai Kazuaki
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • Li Yun-Shan
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • Song Ming-Fen
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • Ootsuyama Yuko
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • Kakehashi Anna
    Department of Pathology, Osaka City University Medical School
  • Wanibuchi Hideki
    Department of Pathology, Osaka City University Medical School
  • Ootsuyama Akira
    Department of Radiation Biology, University of Occupational and Environmental Health
  • Norimura Toshiyuki
    Department of Radiation Biology, University of Occupational and Environmental Health
  • Kasai Hiroshi
    Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

この論文をさがす

抄録

We have reported the formation of 5-methylcytosine from cytosine in vitro, with methyl radicals generated from methionine sulfoxide (MetO). To confirm this reaction in vivo, MetO was added to the drinking water and administered to non-alcoholic steatohepatitis (NASH) mice, which develop hepatitis caused by endogenous oxidative stress. Histopathological examinations revealed incidences of hepatocellular carcinoma of 16.7% and 90% in the 0% and 3% MetO groups, respectively. Higher DNA methylation was detected in the promoter region of the p16 gene isolated from the livers of MetO-treated mice. The higher incidence of liver tumors may be due to the methyl radical-mediated formation of 5-methylcytosine in DNA, which triggers epigenetic changes.<br>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (55)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ