Convection-Enhanced Delivery: From Mechanisms to Clinical Drug Delivery for Diseases of the Central Nervous System

• SAITO Ryuta

  Department of Neurosurgery, Tohoku University Graduate School of Medicine

• TOMINAGA Teiji

  Department of Neurosurgery, Tohoku University Graduate School of Medicine

抄録

The evolution of cancer chemotherapy has been a major advance in medical science in the late 20th century. However, patients with malignant gliomas have not benefitted much. The blood-brain barrier (BBB), which always hinders the entry of therapeutic agents into the central nervous system (CNS), may at least partly be responsible. Convection-enhanced delivery (CED), a method for distributing large and small molecular weight compounds bypassing the BBB, enables robust distribution of the infused molecules at the site of infusion. CED is promising as an effective treatment not only for malignant gliomas but also for multiple CNS disorders because this method can effectively distribute multiple molecules that are potentially effective against different diseases. Although the method is quite simple, several problems require solution in developing novel CED-based strategies, including what, where, when, and how to infuse. This review discusses basic considerations when developing CED-based strategies for CNS diseases, focusing mainly on brain tumors.<br>

収録刊行物

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 52 (8), 531-538, 2012

  一般社団法人 日本脳神経外科学会

キーワード

• convection-enhanced delivery
• blood-brain barrier
• central nervous system
• brain tumor
• drug delivery

詳細情報

• CRID: 1390282680033522432
• NII論文ID: 10030694427
• NII書誌ID: AN00358613
• DOI: 10.2176/nmc.52.531
• COI: 1:STN:280:DC%2BC38bmslylsA%3D%3D
• ISSN: 13498029
• ISSN: 04708105
• PubMed: 22976134
• Web Site: https://www.jstage.jst.go.jp/article/nmc/52/8/52_2012-0128/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013287487
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可