Prognostic Significance of Long-Period Heart Rate Rhythms in Chronic Heart Failure
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- Pastor-Pérez Francisco J.
- Department of Cardiology, Virgen de la Arrixaca University Hospital
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- Manzano-Fernández Sergio
- Department of Cardiology, Virgen de la Arrixaca University Hospital
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- Goya-Esteban Rebeca
- Department of Signal Theory and Communications, University Rey Juan Carlos
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- Pascual-Figal Domingo A.
- Department of Cardiology, Virgen de la Arrixaca University Hospital
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- Barquero-Pérez Oscar
- Department of Signal Theory and Communications, University Rey Juan Carlos
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- Rojo-Álvarez Jose Luis
- Department of Signal Theory and Communications, University Rey Juan Carlos
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- Everss Estrella
- Department of Signal Theory and Communications, University Rey Juan Carlos
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- Martinez Martinez-Espejo Maria Dolores
- Department of Cardiology, Virgen de la Arrixaca University Hospital
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- Valdés Chavarri Mariano
- Department of Cardiology, Virgen de la Arrixaca University Hospital
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- García-Alberola Arcadi
- Department of Cardiology, Virgen de la Arrixaca University Hospital
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Background: Abnormalities in autonomic control are a feature of neuroendocrine activation in HF and are responsible for dysregulation of biological rhythms. The purpose was to investigate the presence and the prognostic significance of long-period heart rate (HR) rhythms in heart failure (HF) patients. Methods and Results: In the study, 92 HF patients were enrolled (age 53±14 years and left ventricular ejection fraction [LVEF] 37±10%). A rhythmometric analysis was used to assess the HR rhythms in 7-days (7D) Holter recordings. Rhythms properties were quantified by mesor and amplitude, in beats/min and by acrophase, in hours. Cardiac death or HF decompensation were registered. All patients had 24-h rhythm, 61 patients (77%) had 8-h rhythm, and 66 patients (83%) had 7D rhythm. Twelve patients (15%) experienced events. Among rhythm parameters only 7D median amplitude was different between patients with or without events: 1.1beats/min [0.5–1.5] vs. 2.0beats/min [0.0–3.9], P=0.049 respectively. After multivariate adjustment, LVEF (per 1%, hazard ratio 0.92, 95% confidence interval (CI) 0.87 to 0.98, P=0.01), N-terminal portion of pro-natriuretic hormone type B (per 100pg/ml, hazard ratio 1.036, 95% CI 1.005–1.069, P=0.022), and 7D amplitude of the HR ≤1.71beats/min (hazard ratio 5.4, 95% CI 1.2–34.4, P=0.047) were independent predictors of events. Conclusions: A 7D HR rhythm is present in most patients with HF, and has prognostic significance. (Circ J 2012; 76: 2124–2129)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 76 (9), 2124-2129, 2012
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205103442432
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- NII論文ID
- 10030696480
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- NII書誌ID
- AA11591968
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- COI
- 1:STN:280:DC%2BC38npsFalsg%3D%3D
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- ISSN
- 13474820
- 13469843
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- PubMed
- 22673367
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
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- 使用不可