Phosphoglucomutase Activity as a Novel Biomarker in Patients With Acute Myocardial Infarction

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  • Nishinari Makoto
    Department of Angio-Cardiology, Kitasato University School of Medicine
  • Aoyama Naoyoshi
    Department of Angio-Cardiology, Kitasato University School of Medicine
  • Ogawa Zensuke
    Department of Clinical Chemistry, Kitasato University School of Allied Health Sciences
  • Yukino Shogo
    Department of Clinical Chemistry, Kitasato University School of Allied Health Sciences
  • Oka Shusaku
    Department of Clinical Chemistry, Kitasato University School of Allied Health Sciences
  • Yano Kouji
    Department of Clinical Chemistry, Kitasato University School of Allied Health Sciences
  • Kurosaki Yoshifumi
    Department of Clinical Chemistry, Kitasato University School of Allied Health Sciences
  • Takeuchi Ichiro
    Department of Angio-Cardiology, Kitasato University School of Medicine
  • Imaki Ryuta
    Department of Angio-Cardiology, Kitasato University School of Medicine
  • Tojo Taiki
    Department of Angio-Cardiology, Kitasato University School of Medicine
  • Shimohama Takao
    Department of Angio-Cardiology, Kitasato University School of Medicine
  • Takehana Hitoshi
    Department of Angio-Cardiology, Kitasato University School of Medicine
  • Izumi Tohru
    Department of Angio-Cardiology, Kitasato University School of Medicine

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Background: Phosphoglucomutase (PGM), a key enzyme in cellular glucose utilization and energy homeostasis, has been reported to show a relationship with oxidative stress. However, the clinical importance of PGM activity has not been investigated in patients with ischemic heart disease (IHD). The aim of the present pilot study was to clarify whether PGM activity has potential as a cardiovascular risk predictor in patients with IHD. Methods and Results: The levels of serum PGM activity in 237 patients with IHD (63 patients with acute myocardial infarction (AMI) and 174 patients with stable effort angina pectoris (EAP)) were evaluated. PGM activity was compared with levels of various myocardial, thrombosis, and inflammatory biomarkers on admission. PGM activity in the AMI group was significantly increased relative to that in the EAP group on admission (AMI, 55.5μmol·min–1·L–1 (U/L); EAP, 14.4U/L (P<0.001)), and was observed to increase in parallel with well-established myocardial markers (P<0.001). Moreover, PGM activity and the lipid, thrombosis, and inflammatory biomarkers in the AMI group were higher than those in the EAP group. Conclusions: PGM activity increased with levels of myocardial, thrombosis, and inflammatory biomarkers in patients with AMI, and might be useful in diagnostic applications during the acute phase in patients with AMI.  (Circ J 2012; 76: 2197–2203)<br>

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  • Circulation Journal

    Circulation Journal 76 (9), 2197-2203, 2012

    一般社団法人 日本循環器学会

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